The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice

doi:10.1084/jem.173.6.1373

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The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice

B Van den Eynde, B Lethe, A Van Pel, E De Plaen and T Boon
Ludwig Institute for Cancer Research, Brussels, Belgium.

We showed previously that mouse mastocytoma P815 expresses several distinct antigens that are recognized by cytolytic T lymphocytes (CTL) of syngeneic DBA/2 mice. Antigens P815A and P815B are usually lost jointly and are targets for immune rejection responses in vivo. We used a cosmid library and a CTL stimulation assay to obtain transfectants expressing tumor rejection antigen P815A. From these transfectants we retrieved gene P1A which transferred the expression of both P815A and B. This gene is unrelated to three previously isolated genes coding for tum-antigens. It encodes a putative protein of 224 amino acids which contains two highly acidic domains showing homology with similar regions of nuclear proteins. The P1A gene expressed by tumor P815 is completely identical to the gene present in normal DBA/2 cells. Expression of the gene was tested by Northern blots. Cells from liver, spleen, and a number of mast cell lines were negative, but mast cell line L138.8A produced a high level of P1A message and was lysed by CTL directed against antigens P815A and B. We conclude that major tumor rejection antigens of P815 are encoded by a gene showing little or no expression in most normal cells of adult mice.
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Iwai, Y., Ishida, M., Tanaka, Y., Okazaki, T., Honjo, T., Minato, N. (2002). Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl. Acad. Sci. USA 99: 12293-12297 [Abstract] [Full Text]
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Haicheur, N., Bismuth, E., Bosset, S., Adotevi, O., Warnier, G., Lacabanne, V., Regnault, A., Desaymard, C., Amigorena, S., Ricciardi-Castagnoli, P., Goud, B., Fridman, W. H., Johannes, L., Tartour, E. (2000). The B Subunit of Shiga Toxin Fused to a Tumor Antigen Elicits CTL and Targets Dendritic Cells to Allow MHC Class I-Restricted Presentation of Peptides Derived from Exogenous Antigens. J. Immunol. 165: 3301-3308 [Abstract] [Full Text]
van Hall, T., van Bergen, J., van Veelen, P. A., Kraakman, M., Heukamp, L. C., Koning, F., Melief, C. J. M., Ossendorp, F., Offringa, R. (2000). Identification of a Novel Tumor-Specific CTL Epitope Presented by RMA, EL-4, and MBL-2 Lymphomas Reveals Their Common Origin. J. Immunol. 165: 869-877 [Abstract] [Full Text]
Narvaiza, I., Mazzolini, G., Barajas, M., Duarte, M., Zaratiegui, M., Qian, C., Melero, I., Prieto, J. (2000). Intratumoral Coinjection of Two Adenoviruses, One Encoding the Chemokine IFN-{gamma}-Inducible Protein-10 and Another Encoding IL-12, Results in Marked Antitumoral Synergy. J. Immunol. 164: 3112-3122 [Abstract] [Full Text]
Huang, J., Yang, Y., Sepulveda, H., Shi, W., Hwang, I., Peterson, P. A., Jackson, M. R., Sprent, J., Cai, Z. (1999). TCR-Mediated Internalization of Peptide-MHC Complexes Acquired by T Cells. Science 286: 952-954 [Abstract] [Full Text]
Wang, F., Bade, E., Kuniyoshi, C., Spears, L., Jeffery, G., Marty, V., Groshen, S., Weber, J. (1999). Phase I Trial of a MART-1 Peptide Vaccine with Incomplete Freund's Adjuvant for Resected High-Risk Melanoma. Clin. Cancer Res. 5: 2756-2765 [Abstract] [Full Text]
Fayolle, C., Ladant, D., Karimova, G., Ullmann, A., Leclerc, C. (1999). Therapy of Murine Tumors with Recombinant Bordetella pertussis Adenylate Cyclase Carrying a Cytotoxic T Cell Epitope. J. Immunol. 162: 4157-4162 [Abstract] [Full Text]
Bilsborough, J., Van Pel, A., Uyttenhove, C., Boon, T., Van den Eynde, B. J. (1999). Identification of a Second Major Tumor-Specific Antigen Recognized by CTLs on Mouse Mastocytoma P815. J. Immunol. 162: 3534-3540 [Abstract] [Full Text]
Sarma, S., Guo, Y., Guilloux, Y., Lee, C., Bai, X.-F., Liu, Y. (1999). Cytotoxic T Lymphocytes to An Unmutated Tumor Rejection Antigen P1A: Normal Development but Restrained Effector Function In Vivo. JEM 189: 811-820 [Abstract] [Full Text]
Luxembourg, A. T., Brunmark, A., Kong, Y., Jackson, M. R., Peterson, P. A., Sprent, J., Cai, Z. (1998). Requirements for Stimulating Naive CD8+ T Cells via Signal 1 Alone. J. Immunol. 161: 5226-5235 [Abstract] [Full Text]
Karimova, G., Fayolle, C., Gmira, S., Ullmann, A., Leclerc, C., Ladant, D. (1998). Charge-dependent translocation of Bordetella pertussis adenylate cyclase toxin into eukaryotic cells: Implication for the in vivo delivery of CD8+ T cell epitopes into antigen-presenting cells. Proc. Natl. Acad. Sci. USA 95: 12532-12537 [Abstract] [Full Text]
Fioretti, F., Fradelizi, D., Stoppacciaro, A., Ramponi, S., Ruco, L., Minty, A., Sozzani, S., Garlanda, C., Vecchi, A., Mantovani, A. (1998). Reduced Tumorigenicity and Augmented Leukocyte Infiltration After Monocyte Chemotactic Protein-3 (MCP-3) Gene Transfer: Perivascular Accumulation of Dendritic Cells in Peritumoral Tissue and Neutrophil Recruitment Within the Tumor. J. Immunol. 161: 342-346 [Abstract] [Full Text]
Toda, M., Martuza, R. L., Kojima, H., Rabkin, S. D. (1998). In Situ Cancer Vaccination: An IL-12 Defective Vector/Replication-Competent Herpes Simplex Virus Combination Induces Local and Systemic Antitumor Activity. J. Immunol. 160: 4457-4464 [Abstract] [Full Text]
Vierboom, M. P.M., Nijman, H. W., Offringa, R., Voort, E. I.H. v. d., Hall, T. v., Broek, L. v. d., Fleuren, G. J., Kenemans, P., Kast, W. M., Melief, C. J.M. (1997). Tumor Eradication by Wild-type p53-specific Cytotoxic T Lymphocytes. JEM 186: 695-704 [Abstract] [Full Text]
Mandruzzato, S., Brasseur, F., Andry, G., Boon, T., Bruggen, P. v. d. (1997). A CASP-8 Mutation Recognized by Cytolytic T Lymphocytes on a Human Head and Neck Carcinoma. JEM 186: 785-793 [Abstract] [Full Text]
Bronte, V., Carroll, M. W., Goletz, T. J., Wang, M., Overwijk, W. W., Marincola, F., Rosenberg, S. A., Moss, B., Restifo, N. P. (1997). Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor�vaccine. Proc. Natl. Acad. Sci. USA 94: 3183-3188 [Abstract] [Full Text]
Chen, Y.-T., Scanlan, M. J., Sahin, U., Tureci, O., Gure, A. O., Tsang, S., Williamson, B., Stockert, E., Pfreundschuh, M., Old, L. J. (1997). A testicular antigen aberrantly expressed in human cancers detected by autologous antibody�screening. Proc. Natl. Acad. Sci. USA 94: 1914-1918 [Abstract] [Full Text]
Cai, Z., Kishimoto, H., Brunmark, A., Jackson, M. R., Peterson, P. A., Sprent, J. (1997). Requirements for Peptide-induced T Cell Receptor Downregulation on Naive CD8+ T Cells. JEM 185: 641-652 [Abstract] [Full Text]
Bloom, M. B., Perry-Lalley, D., Robbins, P. F., Li, Y., El-Gamil, M., Rosenberg, S. A., Yang, J. C. (1997). Identification of Tyrosinase-related Protein 2�as a Tumor Rejection Antigen for the B16 Melanoma. JEM 185: 453-460 [Abstract] [Full Text]
Wolfel, T, Hauer, M, Schneider, J, Serrano, M, Wolfel, C, Klehmann-Hieb, E, De Plaen, E, Hankeln, T, Meyer zum Buschenfelde, K., Beach, D (1995). A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 269: 1281-1284 [Abstract]
Boon, T., Van den Eynde, B., Hirsch, H., Moroni, C., De Plaen, E., van der Bruggen, P., De Smet, C., Lurquin, C., Szikora, J.-P., De Backer, O. (1994). Genes Coding for Tumor-specific Rejection Antigens. Cold Spring Harb Symp Quant Biol 59: 617-622 [Abstract]
Lanzavecchia, A (1993). Identifying strategies for immune intervention. Science 260: 937-944 [Abstract]
van der Bruggen, P, Traversari, C, Chomez, P, Lurquin, C, De Plaen, E, Van den Eynde, B, Knuth, A, Boon, T (1991). A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254: 1643-1647 [Abstract]