Interleukin 10: a novel stimulatory factor for mast cells and their progenitors

doi:10.1084/jem.173.2.507

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Interleukin 10: a novel stimulatory factor for mast cells and their progenitors

L Thompson-Snipes, V Dhar, MW Bond, TR Mosmann, KW Moore and DM Rennick
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304.

We have characterized the mast cell stimulating activity of murine cytokine synthesis inhibitory factor, referred to as interleukin 10 (IL- 10). It was found that IL-10 alone failed to support the growth of mast cell lines and mast cell progenitors. Nevertheless, it dramatically enhanced their growth when combined with IL-3 or IL-4. Moreover, IL-4 plus IL-10 supported the proliferation of mast cells as well as IL-3, suggesting that these two factors may provide a pathway for their development independent of IL-3. However, optimal mast cell growth was stimulated by the combination of IL-10, IL-4, and IL-3. This particular set of cytokines are coordinately produced by activated T cells and may constitute an effective network regulating early and late stages of mast cell development during certain immune responses.
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