Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cells

doi:10.1084/jem.173.2.487

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Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cells

E Roosnek and A Lanzavecchia
Basel Institute for Immunology, Switzerland.

Using Epstein-Barr virus B cell clones and antigen-specific T cell clones, we asked how antigen-antibody complexes are handled by B cells. We found that the only B cells capable of efficient presentation of antigen-antibody complexes are those that bind the complexes via membrane immunoglobulin, i.e., rheumatoid factor-producing B cells and, to a lower extent, antigen-specific B cells. On the contrary, nonspecific B cells, although capable of binding antigen-antibody complexes, fail to present them to T cells. Thus, rheumatoid factor B cells can present any antigen in the context of an immune complex and be triggered by T cells specific for a variety of foreign antigens. These results demonstrate a mechanism of intermolecular help that may be responsible for the production of rheumatoid factor and possibly of other types of autoantibodies.
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Edwards, J. C. W., Cambridge, G. (2005). Prospects for B-cell-targeted therapy in autoimmune disease. Rheumatology (Oxford) 44: 151-156 [Full Text]
Wong, F. S., Wen, L., Tang, M., Ramanathan, M., Visintin, I., Daugherty, J., Hannum, L. G., Janeway, C. A. Jr, Shlomchik, M. J. (2004). Investigation of the Role of B-Cells in Type 1 Diabetes in the NOD Mouse. Diabetes 53: 2581-2587 [Abstract] [Full Text]
Bourke, E., Bosisio, D., Golay, J., Polentarutti, N., Mantovani, A. (2003). The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Blood 102: 956-963 [Abstract] [Full Text]
Spiotto, M. T., Reth, M. A., Schreiber, H. (2003). Genetic changes occurring in established tumors rapidly stimulate new antibody responses. Proc. Natl. Acad. Sci. USA 100: 5425-5430 [Abstract] [Full Text]
Leandro, M J, Edwards, J C W, Cambridge, G (2002). Clinical outcome in 22 patients with rheumatoid arthritis treated with B lymphocyte depletion. Ann Rheum Dis 61: 883-888 [Abstract] [Full Text]
Takemura, S., Klimiuk, P. A., Braun, A., Goronzy, J. J., Weyand, C. M. (2001). T Cell Activation in Rheumatoid Synovium Is B Cell Dependent. J. Immunol. 167: 4710-4718 [Abstract] [Full Text]
Youinou, P, Lydyard, P M (2001). CD5/ B cells in nonorgan-specific autoimmune diseases: a fresh look. Lupus 10: 523-525
Edwards, J. C. W., Cambridge, G. (2001). Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes. Rheumatology (Oxford) 40: 205-211 [Abstract] [Full Text]
Wang, H., Shlomchik, M. J. (1999). Autoantigen-specific B Cell Activation in Fas-deficient Rheumatoid Factor Immunoglobulin Transgenic Mice. J. Exp. Med. 190: 639-650 [Abstract] [Full Text]
Chan, O. T.M., Hannum, L. G., Haberman, A. M., Madaio, M. P., Shlomchik, M. J. (1999). A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus. J. Exp. Med. 189: 1639-1648 [Abstract] [Full Text]
Leonetti, M., Galon, J., Thai, R., Sautes-Fridman, C., Moine, G., Menez, A. (1999). Presentation of Antigen in Immune Complexes Is Boosted by Soluble Bacterial Immunoglobulin Binding Proteins. J. Exp. Med. 189: 1217-1228 [Abstract] [Full Text]
Ivanovski, M., Silvestri, F., Pozzato, G., Anand, S., Mazzaro, C., Burrone, O. R., Efremov, D. G. (1998). Somatic Hypermutation, Clonal Diversity, and Preferential Expression of the VH 51p1/VL kv325 Immunoglobulin Gene Combination in Hepatitis C Virus-Associated Immunocytomas. Blood 91: 2433-2442 [Abstract] [Full Text]
Chan, O., J. Shlomchik, M. (1998). A New Role for B Cells in Systemic Autoimmunity: B Cells Promote Spontaneous T Cell Activation in MRL-lpr/lpr Mice. J. Immunol. 160: 51-59 [Abstract] [Full Text]
Fehr, T., Bachmann, M. F., Bucher, E., Kalinke, U., Padova, F. E.�D., Lang, A. B., Hengartner, H., Zinkernagel, R. M. (1997). Role of Repetitive Antigen Patterns for Induction of Antibodies Against Antibodies. J. Exp. Med. 185: 1785-1792 [Abstract] [Full Text]
SOLTYS, A J, AXFORD, J S, SUTTON, B J (1997). Rheumatoid factors: where are we now?. Ann Rheum Dis 56: 285-286 [Full Text]
Tighe, H., Warnatz, K., Brinson, D., Corr, M., Weigle, W.�O., Baird, S.�M., Carson, D.�A. (1997). Peripheral deletion of rheumatoid factor B cells after abortive activation by�IgG. Proc. Natl. Acad. Sci. USA 94: 646-651 [Abstract] [Full Text]
Winkler, T.H., Kalden, J.R. (1994). Origin of Anti-DNA Autoantibodies in SLE. Lupus 3: 75-76
Amigorena, S, Bonnerot, C, Drake, JR, Choquet, D, Hunziker, W, Guillet, J., Webster, P, Sautes, C, Mellman, I, Fridman, W. (1992). Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes. Science 256: 1808-1812 [Abstract]