Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles

doi:10.1084/jem.173.2.409

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Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles

K Harada and H Yamagishi
Department of Biophysics, Faculty of Science, Kyoto University, Japan.

Circular DNAs excised by immunoglobulin kappa chain gene rearrangements were cloned and characterized. 16 of 17 clones examined were double recombination products containing a V kappa-J kappa rearrangement (coding joint) as well as the reciprocal element (signal joint) of another V kappa-J kappa rearrangement. These products suggested multiple recombination, primary inversion, and secondary excision. In primary events, 5 of 16 translational reading frames were in-phase. Thus, V kappa gene rearrangement may not be inhibited by the presence of a productively rearranged allele. An unusually large trinucleotide (P) insertion forming a palindrome of 12 nucleotides was also observed in one of the coding joints.
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