Enhancement of human basophil histamine release by interleukin 5

doi:10.1084/jem.172.5.1525

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Enhancement of human basophil histamine release by interleukin 5

K Hirai, M Yamaguchi, Y Misaki, T Takaishi, K Ohta, Y Morita, K Ito and T Miyamoto
Department of Medicine and Physical Therapy, University of Tokyo School of Medicine, Japan.

Substantial evidence indicates a close relationship between eosinophils and basophils. We examined whether interleukin 5 (IL-5), known to be eosinophilopoietic and capable of selectively regulating eosinophil functions, has an affect on basophil functions. IL-5 enhanced basophil histamine release evoked by anti-IgE, formyl-methionyl-leucyl- phenylalanine, or ionophore A23187 at picomolar concentrations. Direct action of IL-5 on human basophils was confirmed using highly purified basophil populations. These observations reveal the novel fact that IL- 5 is able to modulate basophil functions as well as eosinophil functions, and suggest that normal human basophils possess functional receptors for IL-5.
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