The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 172, 1509-1512, Copyright © 1990 by Rockefeller University Press

ARTICLES

Widespread intradermal accumulation of mononuclear leukocytes in lepromatous leprosy patients treated systemically with recombinant interferon gamma

C Nathan, K Squires, W Griffo, W Levis, M Varghese, CK Job, AR Nusrat, S Sherwin, S Rappoport and E Sanchez
Department of Medicine, Cornell University Medical College, New York, New York 10021.

Intradermal administration of recombinant interferon gamma (rIFN-gamma) to lepromatous leprosy patients has converted the local histology toward a tuberculoid pattern. However, such changes have been confined to the site of injection. In contrast, in the present study, marked, intradermal accumulation of CD3+, CD4+, CD8+, and CD1a+ T cells and Leu- M5+ mononuclear phagocytes was induced at a distance from the sites of administration, in a dose-dependent manner, by 10 daily intramuscular injections of 10-30 micrograms rIFN-gamma/m2. Mononuclear cell infiltration began within 3 d of onset of rIFN-gamma therapy and persisted at least 8 wk. Intramuscular administration of rIFN-gamma to lepromatous patients receiving concurrent chemotherapy can safely induce widespread histologic features of an upgrading reaction.
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