Late dominance of the inflammatory process in murine influenza by gamma/delta + T cells

doi:10.1084/jem.172.4.1225

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Late dominance of the inflammatory process in murine influenza by gamma/delta + T cells

SR Carding, W Allan, S Kyes, A Hayday, K Bottomly and PC Doherty
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut.

The inflammatory response in the lungs of mice infected with an influenza A virus consists largely of macrophages and CD3+ T cells. Most T lymphocytes recovered before day 7 after infection express mRNA for the T cell receptor alpha/beta (TCR-alpha/beta), while TCR- gamma/delta mRNA+ cells are found at much higher frequency over the next 7 d. The predominant surface phenotype for the TCR-gamma/delta mRNA+ population is CD3+4-8-TCR-alpha/beta-. Some lymphocytes expressing all the known V gamma genes are found in the inflammatory exudate, but V gamma 2+/V gamma 1+ and V gamma 4+ T cells are present at highest frequency. The response is staged, with maximal numbers of V gamma 4+ cells occurring on day 10 after infection, while the predominant phenotype on day 13 is V gamma 2/V gamma 1+. The emerging peak in numbers of V gamma 4+ lymphocytes is paralleled by increasing numbers of macrophages expressing hsp mRNA. The later maxima found for the V gamma 2+/V gamma 1+ T cells is consistent with the possibility that at least some of these lymphocytes are responding to the hsp+ cells and are functioning to resolve the inflammatory process.
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Hampl, J., Schild, H., Litzenberger, C., Baron, M., Crowley, M. P., Chien, Y.-h. (1999). The Specificity of a Weak {gamma}{delta} TCR Interaction Can Be Modulated by the Glycosylation of the Ligand. J. Immunol. 163: 288-294 [Abstract] [Full Text]
Seixas, E. M. G., Langhorne, J. (1999). {gamma}{delta}T Cells Contribute to Control of Chronic Parasitemia in Plasmodium chabaudi Infections in Mice. J. Immunol. 162: 2837-2841 [Abstract] [Full Text]
Arck, P., Dietl, J., Clark, D. (1999). From the Decidual Cell Internet: Trophoblast-Recognizing T Cells. Biol. Reprod. 60: 227-233 [Abstract] [Full Text]
Cardona, A. E., Restrepo, B. I., Jaramillo, J. M., Teale, J. M. (1999). Development of an Animal Model for Neurocysticercosis: Immune Response in the Central Nervous System Is Characterized by a Predominance of {gamma}{delta} T Cells. J. Immunol. 162: 995-1002 [Abstract] [Full Text]
Denkers, E. Y., Gazzinelli, R. T. (1998). Regulation and Function of T-Cell-Mediated Immunity during Toxoplasma gondii Infection. Clin. Microbiol. Rev. 11: 569-588 [Abstract] [Full Text]
Holtappels, R., Podlech, J., Geginat, G., Steffens, H.-P., Thomas, D., Reddehase, M. J. (1998). Control of Murine Cytomegalovirus in the Lungs: Relative but Not Absolute Immunodominance of the Immediate-Early 1�Nonapeptide during the Antiviral Cytolytic T-Lymphocyte Response in Pulmonary Infiltrates. J. Virol. 72: 7201-7212 [Abstract] [Full Text]
Lahn, M., Kalataradi, H., Mittelstadt, P., Pflum, E., Vollmer, M., Cady, C., Mukasa, A., Vella, A. T., Ikle, D., Harbeck, R., O'Brien, R., Born, W. (1998). Early Preferential Stimulation of {gamma}{delta} T Cells by TNF-{alpha}. J. Immunol. 160: 5221-5230 [Abstract] [Full Text]
DiTirro, J., Rhoades, E. R., Roberts, A. D., Burke, J. M., Mukasa, A., Cooper, A. M., Frank, A. A., Born, W. K., Orme, I. M. (1998). Disruption of the Cellular Inflammatory Response to Listeria monocytogenes Infection in Mice with Disruptions in Targeted Genes. Infect. Immun. 66: 2284-2289 [Abstract] [Full Text]
Tough, D. F., Sprent, J. (1998). Lifespan of gamma /delta T Cells. JEM 187: 357-365 [Abstract] [Full Text]
Sciammas, R., Kodukula, P., Tang, Q., Hendricks, R.L., Bluestone, J.A. (1997). T Cell Receptor-gamma /delta Cells Protect Mice from Herpes Simplex Virus Type 1-induced Lethal Encephalitis. JEM 185: 1969-1975 [Abstract] [Full Text]
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McMenamin, C, Pimm, C, McKersey, M, Holt, P. (1994). Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells. Science 265: 1869-1871 [Abstract]