Protein kinase regulates tumor necrosis factor mRNA stability in virus- stimulated astrocytes

doi:10.1084/jem.172.3.989

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Protein kinase regulates tumor necrosis factor mRNA stability in virus- stimulated astrocytes

AP Lieberman, PM Pitha and ML Shin
Department of Pathology, University of Maryland School of Medicine, Baltimore 21201.

Infection of astrocytes with Newcastle disease virus stimulated the production of 1,2-diacylglycerol, and resulted in the kinase-dependent expression of mRNAs encoding tumor necrosis factor (TNF), interferon alpha and beta, and interleukin 6. The half-life of TNF mRNA was significantly decreased in the presence of protein kinase inhibitors H- 7 and staurosporine, but not in the presence of HA1004. In contrast to the decay of TNF mRNA, the half-lives of other cytokine mRNAs were only minimally affected by the kinase inhibitors. These data indicated that the stability of TNF mRNA was regulated through a novel, kinase- dependent pathway.
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