Transfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice

doi:10.1084/jem.172.3.985

This Article

	Full Text (PDF, 334K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Duchosal, M. A.
	Articles by Dixon, F. J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Duchosal, M. A.
	Articles by Dixon, F. J.


Social Bookmarking

	What's this?

ARTICLES

Transfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice

MA Duchosal, PJ McConahey, CA Robinson and FJ Dixon
Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037.

To study the role of peripheral blood leukocytes (PBL) in the pathogenesis of human systemic lupus erythematosus (SLE), we transferred PBL from 5 SLE patients into 15 severe combined immunodeficiency (SCID) mice. Such reconstituted mice showed long-term presence of auto-antibodies characteristic of the donor in their sera, as well as human immunoglobulin deposition, and in some cases mouse C3, in the renal glomeruli. SCID mice repopulated with PBLs from normal donors do not develop serologic abnormalities or immunodeposits. It is concluded that human SLE serology and some associated renal changes can be reproduced solely by PBL transferred from afflicted patients, and that SCID-human-SLE mice may serve as an in vivo laboratory model for the study of human SLE.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Shioji, K., Yuan, Z., Kita, T., Kishimoto, C. (2004). Immunoglobulin treatment suppressed adoptively transferred autoimmune myocarditis in severe combined immunodeficient mice. Am. J. Physiol. Heart Circ. Physiol. 287: H2619-H2625 [Abstract] [Full Text]
Kishimoto, C., Hiraoka, Y., Takamatsu, N., Takada, H., Kamiya, H., Ochiai, H. (2003). An in vivo model of autoimmune post-coxsackievirus B3 myocarditis in severe combined immunodeficiency mouse. Cardiovasc Res 60: 397-403 [Abstract] [Full Text]
Goto, E., Kohrogi, H., Hirata, N., Tsumori, K., Hirosako, S., Hamamoto, J., Fujii, K., Kawano, O., Ando, M. (2000). Human Bronchial Intraepithelial T Lymphocytes as a Distinct T-Cell Subset . Their Long-Term Survival in SCID-Hu Chimeras. Am. J. Respir. Cell Mol. Bio. 22: 405-411 [Abstract] [Full Text]
Fais, S., Lapenta, C., Santini, S. M., Spada, M., Parlato, S., Logozzi, M., Rizza, P., Belardelli, F. (1999). Human Immunodeficiency Virus Type 1 Strains R5 and X4 Induce Different Pathogenic Effects in hu-PBL-SCID Mice, Depending on the State of Activation/Differentiation of Human Target Cells at the Time of Primary Infection. J. Virol. 73: 6453-6459 [Abstract] [Full Text]
Legrand, F., Khazaal, I., Peuchmaur, M., Fenneteau, O., Cave, H., Rohrlich, P., Vilmer, E., Peault, B. (1997). Long-Term Malignant Hematopoiesis in Human Acute Leukemia Bone Marrow Biopsies Implanted in Severe Combined Immunodeficiency Mice. Blood 90: 2001-2009 [Abstract] [Full Text]
Furukawa, F. (1997). Animal models of cutaneous lupus erythematosus and lupus erythematosus photosensitivity. Lupus 6: 193-202