DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma

doi:10.1084/jem.171.3.965

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DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma

T Blankenstein, ZH Qin, WQ Li and T Diamantstein
Institut fur Immunologie, Klinikum Steglitz, Freie Universitat Berlin, Federal Republic of Germany.

To study the potential involvement of IL-6 in the development of plasmacytomas, a number of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement due to the insertion of an intracisternal A particle retrotransposon 18 bp 5' of the transcriptional start site was detected in the cell line MPC11. The IL- 6 gene is constitutively expressed in MPC11, suggesting the involvement of IL-6 in the development of certain myeloma/plasmacytomas according to the "autocrine growth hypothesis".
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