Journal of Experimental Medicine, Vol 170, 2183-2188, Copyright © 1989 by Rockefeller University Press

CORRECTIONS

In individual T cells one productive alpha rearrangement does not appear to block rearrangement at the second allele [retracted by Hood L, Urban JL. In: J Exp Med 1990 Sep 1;172(3):1005]

V Kumar, JL Urban and L Hood
Division of Biology, California Institute of Technology, Pasadena 91125.

The T cell lymphoma line BW5147 has rearranged TCR alpha chain genes segments on both the homologous chromosomes: one is functional (V alpha 1) and the second (V alpha 16.1) is a pseudogene. The extreme 3' position of the V alpha 16.1 gene segment in the V alpha locus allows us to recognize rearrangements of most V alpha gene segments using the V alpha 16 probe as a marker. The absence of the genomic V alpha 16.1 gene fragment in mature thymocytes, antigen-specific T cells, and in more than two-thirds of the peripheral T cells suggests that most T lymphocytes rearrange both alpha loci. It appears that productive alpha chain rearrangement on one allele probably does not block a subsequent rearrangement on the other alpha locus.
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