Interleukin 3 and interleukin 6 synergistically promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma

doi:10.1084/jem.170.2.613

This Article

Full Text (PDF)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Bergui, L.

Articles by Caligaris-Cappio, F.

Search for Related Content

PubMed

PubMed Citation

Articles by Bergui, L.

Articles by Caligaris-Cappio, F.

Pubmed/NCBI databases

Medline Plus Health Information
Substance via MeSH
Multiple Myeloma

Social Bookmarking

What's this?

ARTICLES

Interleukin 3 and interleukin 6 synergistically promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma

L Bergui, M Schena, G Gaidano, M Riva and F Caligaris-Cappio
Cattedra di Clinica Medica A, Dipartimento di Scienze Biomediche e Oncologia Umana, Universita di Torino, Italy.

PBMC from 11 patients with multiple myeloma (MM) were cultured in vitro in presence of IL-3 and IL-6. After 3 d, actively proliferating immunoblast-like B cells (20-62%) were apparent. After 6 d, a population of morphologically evident plasma cells was observed (30- 50%) that expressed, in each individual case, the same light and heavy chain produced by bone marrow malignant plasma cells. We conclude that in MM the malignant plasma cell precursors are circulating and their growth and terminal differentiation are under the synergistic control of IL-3 and IL-6.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Lee, J. W., Chung, H. Y., Ehrlich, L. A., Jelinek, D. F., Callander, N. S., Roodman, G. D., Choi, S. J. (2004). IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells. Blood 103: 2308-2315 [Abstract] [Full Text]
Qiang, Y.-W., Kopantzev, E., Rudikoff, S. (2002). Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk. Blood 99: 4138-4146 [Abstract] [Full Text]
Aldinucci, D., Poletto, D., Gloghini, A., Nanni, P., Degan, M., Perin, T., Ceolin, P., Rossi, F. M., Gattei, V., Carbone, A., Pinto, A. (2002). Expression of Functional Interleukin-3 Receptors on Hodgkin and Reed-Sternberg Cells. Am. J. Pathol. 160: 585-596 [Abstract] [Full Text]
Silvestris, F., Tucci, M., Cafforio, P., Dammacco, F. (2001). Fas-L up-regulation by highly malignant myeloma plasma cells: role in the pathogenesis of anemia and disease progression. Blood 97: 1155-1164 [Abstract] [Full Text]
Frassanito, M. A., Cusmai, A., Iodice, G., Dammacco, F. (2001). Autocrine interleukin-6 production and highly malignant multiple myeloma: relation with resistance to drug-induced apoptosis. Blood 97: 483-489 [Abstract] [Full Text]
Ge, N.-L., Rudikoff, S. (2000). Insulin-like growth factor I is a dual effector of multiple myeloma cell growth. Blood 96: 2856-2861 [Abstract] [Full Text]
Yaccoby, S., Epstein, J. (1999). The Proliferative Potential of Myeloma Plasma Cells Manifest in the SCID-hu Host. Blood 94: 3576-3582 [Abstract] [Full Text]
Yaccoby, S., Barlogie, B., Epstein, J. (1998). Primary Myeloma Cells Growing in SCID-hu Mice: A Model for Studying the Biology and Treatment of Myeloma and Its Manifestations. Blood 92: 2908-2913 [Abstract] [Full Text]