Acquired resistance to Listeria monocytogenes is mediated by Lyt-2+ T cells independently of the influx of monocytes into granulomatous lesions

doi:10.1084/jem.170.2.589

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Mielke, M. E.
	Articles by Hahn, H.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Mielke, M. E.
	Articles by Hahn, H.


Social Bookmarking

	What's this?

ARTICLES

Acquired resistance to Listeria monocytogenes is mediated by Lyt-2+ T cells independently of the influx of monocytes into granulomatous lesions

ME Mielke, G Niedobitek, H Stein and H Hahn
Department of Medical Microbiology, Klinikum Steglitz, Freie Universitat Berlin, Federal Republic of Germany.

Facultative intracellular bacteria induce specific T cell responses of both the CD4+ and the CD8+ subsets. The immunohistological study of the tissue responses to Listeria monocytogenes in T cell subset-depleted, Listeria-primed mice revealed that CD4+ cells not only represent the predominant lymphocyte population in granulomatous lesions but mediate the attraction and accumulation of blood-borne monocytes into inflammatory foci. On the other hand, CD8+ T cells are able to mediate protection in the absence of CD4+ T cells, invading monocytes, and granulomatous inflammation, and therefore appear to activate resident macrophages for listericidal activity.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Narni-Mancinelli, E., Campisi, L., Bassand, D., Cazareth, J., Gounon, P., Glaichenhaus, N., Lauvau, G. (2007). Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes. J. Exp. Med. 204: 2075-2087 [Abstract] [Full Text]
Bitsaktsis, C., Winslow, G. (2006). Fatal Recall Responses Mediated by CD8 T cells during Intracellular Bacterial Challenge Infection. J. Immunol. 177: 4644-4651 [Abstract] [Full Text]
Lauterbach, H., Kerksiek, K. M., Busch, D. H., Berto, E., Bozac, A., Mavromara, P., Manservigi, R., Epstein, A. L., Marconi, P., Brocker, T. (2004). Protection from Bacterial Infection by a Single Vaccination with Replication-Deficient Mutant Herpes Simplex Virus Type 1. J. Virol. 78: 4020-4028 [Abstract] [Full Text]
Irons, R., Anderson, M. J., Zhang, M., Fritsche, K. L. (2003). Dietary Fish Oil Impairs Primary Host Resistance Against Listeria monocytogenes More than the Immunological Memory Response. J. Nutr. 133: 1163-1169 [Abstract] [Full Text]
Pope, C., Kim, S.-K., Marzo, A., Williams, K., Jiang, J., Shen, H., Lefrancois, L. (2001). Organ-Specific Regulation of the CD8 T Cell Response to Listeria monocytogenes Infection. J. Immunol. 166: 3402-3409 [Abstract] [Full Text]
Murray, H. W. (2000). Mononuclear Cell Recruitment, Granuloma Assembly, and Response to Treatment in Experimental Visceral Leishmaniasis: Intracellular Adhesion Molecule 1-Dependent and -Independent Regulation. Infect. Immun. 68: 6294-6299 [Abstract] [Full Text]
White, D. W., Badovinac, V. P., Fan, X., Harty, J. T. (2000). Adaptive Immunity against Listeria monocytogenes in the Absence of Type I Tumor Necrosis Factor Receptor p55. Infect. Immun. 68: 4470-4476 [Abstract] [Full Text]
White, D. W., Badovinac, V. P., Kollias, G., Harty, J. T. (2000). Cutting Edge: Antilisterial Activity of CD8+ T Cells Derived from TNF-Deficient and TNF/Perforin Double-Deficient Mice. J. Immunol. 165: 5-9 [Abstract] [Full Text]
Badovinac, V. P., Harty, J. T. (2000). Adaptive Immunity and Enhanced CD8+ T Cell Response to Listeria monocytogenes in the Absence of Perforin and IFN-{gamma}. J. Immunol. 164: 6444-6452 [Abstract] [Full Text]
Ochsenbein, A. F., Karrer, U., Klenerman, P., Althage, A., Ciurea, A., Shen, H., Miller, J. F., Whitton, J. L., Hengartner, H., Zinkernagel, R. M. (1999). A comparison of T cell memory against the same antigen induced by virus versus intracellular bacteria. Proc. Natl. Acad. Sci. USA 96: 9293-9298 [Abstract] [Full Text]
Way, S. S., Borczuk, A. C., Goldberg, M. B. (1999). Thymic Independence of Adaptive Immunity to the Intracellular Pathogen Shigella flexneri Serotype 2a. Infect. Immun. 67: 3970-3979 [Abstract] [Full Text]
Schmitz, J. E., Simon, M. A., Kuroda, M. J., Lifton, M. A., Ollert, M. W., Vogel, C.-W., Racz, P., Tenner-Racz, K., Scallon, B. J., Dalesandro, M., Ghrayeb, J., Rieber, E. P., Sasseville, V. G., Reimann, K. A. (1999). A Nonhuman Primate Model for the Selective Elimination of CD8+ Lymphocytes Using a Mouse-Human Chimeric Monoclonal Antibody. Am. J. Pathol. 154: 1923-1932 [Abstract] [Full Text]
White, D. W., MacNeil, A., Busch, D. H., Pilip, I. M., Pamer, E. G., Harty, J. T. (1999). Perforin-Deficient CD8+ T Cells: In Vivo Priming and Antigen-Specific Immunity Against Listeria monocytogenes. J. Immunol. 162: 980-988 [Abstract] [Full Text]
Geginat, G., Lalic, M., Kretschmar, M., Goebel, W., Hof, H., Palm, D., Bubert, A. (1998). Th1 Cells Specific for a Secreted Protein of Listeria monocytogenes Are Protective In Vivo. J. Immunol. 160: 6046-6055 [Abstract] [Full Text]
Steinhoff, U., Klemm, U., Greiner, M., Bordasch, K., Kaufmann, S. H. E. (1998). Altered Intestinal Immune System but Normal Antibacterial Resistance in the Absence of P-Selectin and ICAM-1. J. Immunol. 160: 6112-6120 [Abstract] [Full Text]
DiTirro, J., Rhoades, E. R., Roberts, A. D., Burke, J. M., Mukasa, A., Cooper, A. M., Frank, A. A., Born, W. K., Orme, I. M. (1998). Disruption of the Cellular Inflammatory Response to Listeria monocytogenes Infection in Mice with Disruptions in Targeted Genes. Infect. Immun. 66: 2284-2289 [Abstract] [Full Text]
White, D. W., Harty, J. T. (1998). Perforin-Deficient CD8+ T Cells Provide Immunity to Listeria monocytogenes by a Mechanism That Is Independent of CD95 and IFN-{gamma} but Requires TNF-{alpha}. J. Immunol. 160: 898-905 [Abstract] [Full Text]