The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 170, 583-588, Copyright © 1989 by Rockefeller University Press

ARTICLES

Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity

T Aoki, H Kikuchi, S Miyatake, Y Oda, K Iwasaki, T Yamasaki, T Kinashi and T Honjo
Department of Neurosurgery, Faculty of Medicine, Kyoto University, Japan.

IL-5 expresses various biologic effects on several types of lymphocytes, including B cells, eosinophils, and T cells. We demonstrated that the incubation of resting splenocytes from C57BL/6 mice in murine rIL-5 enhances IL-2-mediated lymphokine-activated killer (LAK) activity against various tumor cells. IL-5 alone, however, does not induce killer activity. IL-2-mediated LAK activity increases in proportion to the dose of IL-5. During the late phase of the culture period, IL-5 seems to have some effect on the induction of IL-2- mediated LAK activity. We expect that IL-5 will prove useful for adoptive immunotherapy.
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