Inhibition of human macrophage colony formation by interleukin 4

doi:10.1084/jem.170.2.577

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Inhibition of human macrophage colony formation by interleukin 4

JH Jansen, GJ Wientjens, WE Fibbe, R Willemze and HC Kluin-Nelemans
Department of Hematology, Leiden University Medical Center, The Netherlands.

We investigated the effects of human rIL-4 on in vitro hematopoiesis. A profound inhibition of macrophage colony formation by IL-4 was observed, whereas colony growth of other lineages was not affected. Inhibition of macrophage colony growth was not restricted to GM-CSF- induced colony growth but was also present in cultures stimulated with M-CSF. This inhibition was not only observed in cultures of light density bone marrow cells, but also in cultures of monocyte- and T lymphocyte-depleted bone marrow cells. Since a similar inhibition was observed in cultures of CD34+HLA-DR+-enriched bone marrow cells, a direct action of IL-4 on monocyte-committed progenitor cells is suggested.
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