Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions

doi:10.1084/jem.170.2.481

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Ravetch, J. V.
	Articles by Perussia, B.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Ravetch, J. V.
	Articles by Perussia, B.


Social Bookmarking

	What's this?

ARTICLES

Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions

JV Ravetch and B Perussia
DeWitt Wallace Research Laboratory, Sloan-Kettering Institute, New York, New York 10021.

A low affinity receptor for IgG immune complexes, Fc gamma RIII(CD16), is expressed on human NK cells as an integral membrane glycoprotein anchored through a transmembrane peptide; on polymorphonuclear neutrophils (PMN) the receptor is anchored through a phosphatidylinositol (PI) linkage. The protein on NK cells has a molecular mass 6-10 kD larger than that on PMN, and, unlike the latter, is resistant to PI-specific phospholipase C (PI-PLC). Fc gamma RIII(CD16) transcripts isolated from PMN and NK cells of single donors revealed multiple single nucleotide differences, one of which converts an in frame UGA termination codon to a CGA codon. The resulting open reading frame encodes a longer cytoplasmic domain for Fc gamma RIII(CD16) in NK cells, contributing to its transmembrane anchor. Two nearly identical, linked genes that encode these transcripts have been cloned for Fc gamma RIII(CD16), one of which (III-1) is allelic for NA- 1 and NA-2. The allelic sites have been mapped to two single nucleotides in the extracellular domain. These genes are transcribed in a cell type-specific fashion to generate the alternatively anchored forms of this receptor.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Cartron, G., Ohresser, M., Salles, G., Solal-Celigny, P., Colombat, P., Watier, H. (2008). Neutrophil role in in vivo anti-lymphoma activity of rituximab: FCGR3B-NA1/NA2 polymorphism does not influence response and survival after rituximab treatment. Ann Oncol 19: 1485-1487 [Abstract] [Full Text]
Willcocks, L. C., Lyons, P. A., Clatworthy, M. R., Robinson, J. I., Yang, W., Newland, S. A., Plagnol, V., McGovern, N. N., Condliffe, A. M., Chilvers, E. R., Adu, D., Jolly, E. C., Watts, R., Lau, Y. L., Morgan, A. W., Nash, G., Smith, K. G.C. (2008). Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake. J. Exp. Med. 205: 1573-1582 [Abstract] [Full Text]
Forthal, D. N., Landucci, G., Bream, J., Jacobson, L. P., Phan, T. B., Montoya, B. (2007). Fc{gamma}RIIa Genotype Predicts Progression of HIV Infection. J. Immunol. 179: 7916-7923 [Abstract] [Full Text]
Forthal, D. N., Gilbert, P. B., Landucci, G., Phan, T. (2007). Recombinant gp120 Vaccine-Induced Antibodies Inhibit Clinical Strains of HIV-1 in the Presence of Fc Receptor-Bearing Effector Cells and Correlate Inversely with HIV Infection Rate. J. Immunol. 178: 6596-6603 [Abstract] [Full Text]
Rogers, K. A., Scinicariello, F., Attanasio, R. (2006). IgG Fc Receptor III Homologues in Nonhuman Primate Species: Genetic Characterization and Ligand Interactions. J. Immunol. 177: 3848-3856 [Abstract] [Full Text]
Stafford, J. L., Wilson, M., Nayak, D., Quiniou, S. M., Clem, L. W., Miller, N. W., Bengten, E. (2006). Identification and Characterization of a FcR Homolog in an Ectothermic Vertebrate, the Channel Catfish (Ictalurus punctatus). J. Immunol. 177: 2505-2517 [Abstract] [Full Text]
Ferrara, C., Stuart, F., Sondermann, P., Brunker, P., Umana, P. (2006). The Carbohydrate at Fc{gamma}RIIIa Asn-162: AN ELEMENT REQUIRED FOR HIGH AFFINITY BINDING TO NON-FUCOSYLATED IgG GLYCOFORMS. J. Biol. Chem. 281: 5032-5036 [Abstract] [Full Text]
Webster, N. L., Kedzierska, K., Azzam, R., Paukovics, G., Wilson, J., Crowe, S. M., Jaworowski, A. (2006). Phagocytosis stimulates mobilization and shedding of intracellular CD16A in human monocytes and macrophages: inhibition by HIV-1 infection. J. Leukoc. Biol. 79: 294-302 [Abstract] [Full Text]
Brown, E. E., Fallin, M. D., Goedert, J. J., Chen, R., Whitby, D., Foster, C. B., Lauria, C., Alberg, A. J., Messina, A., Montella, M., Rezza, G., Vitale, F., Chanock, S. J., the Kaposi Sarcoma Genetics Working Group, (2005). A Common Genetic Variant in FCGR3A-V158F and Risk of Kaposi Sarcoma Herpesvirus Infection and Classic Kaposi Sarcoma. Cancer Epidemiol. Biomarkers Prev. 14: 633-637 [Abstract] [Full Text]
Thum, M.Y., Bhaskaran, S., Abdalla, H.I., Ford, B., Sumar, N., Shehata, H., Bansal, A.S. (2004). An increase in the absolute count of CD56dimCD16+CD69+ NK cells in the peripheral blood is associated with a poorer IVF treatment and pregnancy outcome. Hum Reprod 19: 2395-2400 [Abstract] [Full Text]
Sweeney, S. E., Kim, Y. B. (2004). Identification of a Novel Fc{gamma}RIIIa{alpha}-Associated Molecule That Contains Significant Homology to Porcine Cathelin. J. Immunol. 172: 1203-1212 [Abstract] [Full Text]
Jongstra-Bilen, J., Harrison, R., Grinstein, S. (2003). Fc{gamma}-receptors Induce Mac-1 (CD11b/CD18) Mobilization and Accumulation in the Phagocytic Cup for Optimal Phagocytosis. J. Biol. Chem. 278: 45720-45729 [Abstract] [Full Text]
Rocha, V., Franco, R. F., Porcher, R., Bittencourt, H., Silva, W. A. Jr, Latouche, A., Devergie, A., Esperou, H., Ribaud, P., Socie, G., Zago, M. A., Gluckman, E. (2002). Host defense and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplantation. Blood 100: 3908-3918 [Abstract] [Full Text]
Milicic, A, Misra, R, Agrawal, S, Aggarwal, A, Brown, M A, Wordsworth, B P (2002). The F158V polymorphism in Fc{gamma}RIIIA shows disparate associations with rheumatoid arthritis in two genetically distinct populations. Ann Rheum Dis 61: 1021-1023 [Abstract] [Full Text]
Heusohn, F., Wirries, G., Schmidt, R. E., Gessner, J. E. (2002). The Pmed1 Gene Promoter of Human Fc{gamma}RIIIA Can Function as a NK/T Cell-Specific Restriction Element, Which Involves Binding of Sp1 Transcription Factor. J. Immunol. 168: 2857-2864 [Abstract] [Full Text]
Desaulniers, P., Fernandes, M., Gilbert, C., Bourgoin, S. G., Naccache, P. H. (2001). Crystal-induced neutrophil activation. VII. Involvement of Syk in the responses to monosodium urate crystals. J. Leukoc. Biol. 70: 659-668 [Abstract] [Full Text]
Forthal, D. N., Landucci, G., Daar, E. S. (2001). Antibody from Patients with Acute Human Immunodeficiency Virus (HIV) Infection Inhibits Primary Strains of HIV Type 1 in the Presence of Natural-Killer Effector Cells. J. Virol. 75: 6953-6961 [Abstract] [Full Text]
, , , , , , , A., , , , (2000). Involvement of LAT, Gads, and Grb2 in Compartmentation of SLP-76 to the Plasma. J. Exp. Med. 192: 847-856 [Abstract] [Full Text]
van Schie, R. C. A. A., Wilson, M. E. (2000). Evaluation of Human Fcgamma RIIA (CD32) and Fcgamma RIIIB (CD16) Polymorphisms in Caucasians and African-Americans Using Salivary DNA. CVI 7: 676-681 [Abstract] [Full Text]
Chesla, S. E., Li, P., Nagarajan, S., Selvaraj, P., Zhu, C. (2000). The Membrane Anchor Influences Ligand Binding Two-dimensional Kinetic Rates and Three-dimensional Affinity of Fcgamma RIII (CD16). J. Biol. Chem. 275: 10235-10246 [Abstract] [Full Text]
Nagarajan, S., Venkiteswaran, K., Anderson, M., Sayed, U., Zhu, C., Selvaraj, P. (2000). Cell-specific, activation-dependent regulation of neutrophil CD32A ligand-binding function. Blood 95: 1069-1077 [Abstract] [Full Text]
Cuervo, A., Dice, J. (2000). Unique properties of lamp2a compared to other lamp2 isoforms. J. Cell Sci. 113: 4441-4450 [Abstract]
Giembycz, M. A., Lindsay, M. A. (1999). Pharmacology of the Eosinophil. Pharmacol. Rev. 51: 213-340 [Abstract] [Full Text]
Bux, J., Kissel, K., Hofmann, C., Santoso, S. (1999). The Use of Allele-Specific Recombinant Fcgamma Receptor IIIb Antigens for the Detection of Granulocyte Antibodies. Blood 93: 357-362 [Abstract] [Full Text]
Dietrich, J., Geisler, C. (1998). T Cell Receptor zeta �Allows Stable Expression of Receptors Containing the CD3gamma Leucine-based Receptor-sorting Motif. J. Biol. Chem. 273: 26281-26284 [Abstract] [Full Text]
Rukavina, D., Laskarin, G., Rubesa, G., Strbo, N., Bedenicki, I., Manestar, D., Glavas, M., Christmas, S. E., Podack, E. R. (1998). Age-Related Decline of Perforin Expression in Human Cytotoxic T Lymphocytes and Natural Killer Cells. Blood 92: 2410-2420 [Abstract] [Full Text]
Anumanthan, A., Bensussan, A., Boumsell, L., Christ, A. D., Blumberg, R. S., Voss, S. D., Patel, A. T., Robertson, M. J., Nadler, L. M., Freeman, G. J. (1998). Cloning of BY55, a Novel Ig Superfamily Member Expressed on NK Cells, CTL, and Intestinal Intraepithelial Lymphocytes. J. Immunol. 161: 2780-2790 [Abstract] [Full Text]
Maeda, A., Kurosaki, M., Kurosaki, T. (1998). Paired Immunoglobulin-like Receptor (PIR)-A Is Involved in Activating Mast Cells through Its Association with Fc Receptor gamma �Chain. J. Exp. Med. 188: 991-995 [Abstract] [Full Text]
Zhu, X., Hamann, K. J., Munoz, N. M., Rubio, N., Mayer, D., Hernrreiter, A., Leff, A. R. (1998). Intracellular Expression of Fc{gamma}RIII (CD16) and Its Mobilization by Chemoattractants in Human Eosinophils. J. Immunol. 161: 2574-2579 [Abstract] [Full Text]
Green, J. M., Schreiber, A. D., Brown, E. J. (1997). Role for a Glycan Phosphoinositol Anchor in Fcgamma Receptor Synergy. J. Cell Biol. 139: 1209-1217 [Abstract] [Full Text]
Koene, H. R., Kleijer, M., Algra, J., Roos, D., E.G.Kr. von dem Borne, A., de Haas, M. (1997). Fcgamma RIIIa-158V/F Polymorphism Influences the Binding of IgG by Natural Killer Cell Fcgamma RIIIa, Independently of the Fcgamma RIIIa-48L/R/H Phenotype. Blood 90: 1109-1114 [Abstract] [Full Text]
(1997). Corrections for vol. 184, p. 1845. J. Exp. Med. 185: 1149-1150 [Full Text]
Bux, J., Stein, E.-L., Bierling, P., Fromont, P., Clay, M., Stroncek, D., Santoso, S. (1997). Characterization of a New Alloantigen (SH) on the Human Neutrophil Fcgamma receptor IIIb. Blood 89: 1027-1034 [Abstract] [Full Text]
Yanagi, S., Sugawara, H., Kurosaki, M., Sabe, H., Yamamura, H., Kurosaki, T. (1996). CD45 Modulates Phosphorylation of Both Autophosphorylation and Negative Regulatory Tyrosines of Lyn in B Cells. J. Biol. Chem. 271: 30487-30492 [Abstract] [Full Text]
Gessner, J. E., Grussenmeyer, T., Dumbsky, M., Schmidt, R. E. (1996). Separate Promoters from Proximal and Medial Control Regions Contribute to the Natural Killer Cell-specific Transcription of the Human Fcgamma RIII-A (CD16-A) Receptor Gene. J. Biol. Chem. 271: 30755-30764 [Abstract] [Full Text]
Hou, X., Dietrich, J., Odum, N., Geisler, C. (1996). The Cytoplasmic Tail of Fcgamma RIIIAalpha Is Involved in Signaling by the Low Affinity Receptor for Immunoglobulin G. J. Biol. Chem. 271: 22815-22822 [Abstract] [Full Text]
Tamm, A., Kister, A., Nolte, K. U., Gessner, J. E., Schmidt, R. E. (1996). The IgG Binding Site of Human Fc[IMAGE]RIIIB Receptor Involves CC` and FG Loops of the Membrane-proximal Domain. J. Biol. Chem. 271: 3659-3666 [Abstract] [Full Text]
Nagarajan, S., Chesla, S., Cobern, L., Anderson, P., Zhu, C., Selvaraj, P. (1995). Ligand Binding and Phagocytosis by CD16 (Fc [IMAGE] Receptor III) Isoforms. J. Biol. Chem. 270: 25762-25770 [Abstract] [Full Text]
Hulett, M. D., Witort, E., Brinkworth, R. I., McKenzie, I. F. C., Hogarth, P. M. (1995). Multiple Regions of Human Fc[IMAGE]RII (CD32) Contribute to the Binding of IgG. J. Biol. Chem. 270: 21188-21194 [Abstract] [Full Text]
Gessner, J. E., Grussenmeyer, T., Kolanus, W., Schmidt, R. E. (1995). The Human Low Affinity Immunoglobulin G Fc Receptor III-A and III-B Genes. J. Biol. Chem. 270: 1350-1361 [Abstract] [Full Text]
Amigorena, S, Bonnerot, C, Drake, JR, Choquet, D, Hunziker, W, Guillet, J., Webster, P, Sautes, C, Mellman, I, Fridman, W. (1992). Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes. Science 256: 1808-1812 [Abstract]
Hibbs, M., Selvaraj, P, Carpen, O, Springer, T., Kuster, H, Jouvin, M., Kinet, J. (1989). Mechanisms for regulating expression of membrane isoforms of Fc gamma RIII (CD16). Science 246: 1608-1611 [Abstract]
Lanier, L., Cwirla, S, Yu, G, Testi, R, Phillips, J. (1989). Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid. Science 246: 1611-1613 [Abstract]
Kobayashi, N., Suzuki, Y., Tsuge, T., Okumura, K., Ra, C., Tomino, Y. (2002). FcRn-mediated transcytosis of immunoglobulin G in human renal proximal tubular epithelial cells. Am. J. Physiol. Renal Physiol. 282: F358-F365 [Abstract] [Full Text]