The Journal of Experimental Medicine
Accuri Cytometers
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Journal of Experimental Medicine, Vol 170, 327-332, Copyright © 1989 by Rockefeller University Press

ARTICLES

Two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein

T Francus, G Manzo, M Canki, LC Thompson and P Szabo
Division of Allergy and Immunology, Cornell University Medical College, New York, New York 10021.

We have previously shown that tobacco glycoprotein (TGP), a polyphenol- rich glycoprotein isolated from tobacco or from cigarette smoke, affects the immune system. In this study we show that TGP induces human PBL and adherent cells to produce IL-1 alpha and IL-1 beta. Two peaks of IL-1 activity were observed; one at 18-24 h, the second at 4-6 d after initiation of culture. A similar pattern was observed for the steady state level of IL-1 mRNA. These data suggest that the production of IL-1 by cells stimulated with TGP might be a factor in cardiovascular disease associated with cigarette smoking.
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