Establishment of human double-positive thymocyte clones

doi:10.1084/jem.170.1.303

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Establishment of human double-positive thymocyte clones

G De Libero and A Lanzavecchia
Basel Institute for Immunology, Switzerland.

Human thymocytes were sorted according to the expression of CD4 and CD8 molecules and clones representing the four subpopulations (DP, DN, and single CD4 or CD8 positive) were established. DP clones can be maintained for long periods in tissue culture and give rise to a variable percentage of SP variants. These variants, when isolated and further expanded, do not revert to a DP phenotype. DP clones express a functional TCR-CD3 complex, suggesting that this molecule can interact with the thymic microenvironment during T cell differentiation.
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Res, P., Blom, B., Hori, T., Weijer, K., Spits, H. (1997). Downregulation of CD1 Marks Acquisition of Functional Maturation of Human Thymocytes and Defines a Control Point in Late Stages of Human T Cell Development. J. Exp. Med. 185: 141-152 [Abstract] [Full Text]