Identification of a subset of murine natural killer cells that mediates rejection of Hh-1d but not Hh-1b bone marrow grafts

doi:10.1084/jem.170.1.191

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Sentman, C. L.
	Articles by Bennett, M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Sentman, C. L.
	Articles by Bennett, M.


Social Bookmarking

	What's this?

ARTICLES

Identification of a subset of murine natural killer cells that mediates rejection of Hh-1d but not Hh-1b bone marrow grafts

CL Sentman, J Hackett Jr, V Kumar and M Bennett
Department of Pathology and the Immunology Graduate Program, University of Texas Southwestern Medical Center, Dallas 75235.

NK cells demonstrate many immune functions both in vitro and in vivo, including the lysis of tumor or virus-infected cells and the rejection of bone marrow allografts. However it remains unclear whether or not all NK cells can mediate these various functions or if NK cells exist in functionally distinct subsets. We have developed a new NK-specific mAb, SW5E6, which binds to approximately 50% of murine NK cells. The 5E6 antigen identifies a distinct and stable subset of NK cells and is expressed on about one-half of fresh or rIL-2-activated murine NK cells. Both 5E6+ and 5E6- NK cells are capable of lysing YAC-1 tumor cells in vitro and in vivo. By treating animals with SW5E6, we demonstrate that the 5E6+ subset is necessary for the rejection of H- 2d/Hh-1d but not H-2b/Hh-1b bone marrow cells. Thus NK cells exist as functionally separable subsets in vivo.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Lundqvist, A., Philip McCoy, J., Samsel, L., Childs, R. (2007). Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors. Blood 109: 3603-3606 [Abstract] [Full Text]
Brehm, M. A., Daniels, K. A., Ortaldo, J. R., Welsh, R. M. (2005). Rapid Conversion of Effector Mechanisms from NK to T Cells during Virus-Induced Lysis of Allogeneic Implants In Vivo. J. Immunol. 174: 6663-6671 [Abstract] [Full Text]
Fernandez, N. C., Treiner, E., Vance, R. E., Jamieson, A. M., Lemieux, S., Raulet, D. H. (2005). A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules. Blood 105: 4416-4423 [Abstract] [Full Text]
Raziuddin, A., Longo, D. L., Bennett, M., Winkler-Pickett, R., Ortaldo, J. R., Murphy, W. J. (2002). Increased bone marrow allograft rejection by depletion of NK cells expressing inhibitory Ly49 NK receptors for donor class I antigens. Blood 100: 3026-3033 [Abstract] [Full Text]
Xu, H., Exner, B. G., Cramer, D. E., Tanner, M. K., Mueller, Y. M., Ildstad, S. T. (2002). CD8+, {alpha}{beta}-TCR+, and {gamma}{delta}-TCR+ Cells in the Recipient Hematopoietic Environment Mediate Resistance to Engraftment of Allogeneic Donor Bone Marrow. J. Immunol. 168: 1636-1643 [Abstract] [Full Text]
Sundback, J., Achour, A., Michaelsson, J., Lindstrom, H., Karre, K. (2002). NK Cell Inhibitory Receptor Ly-49C Residues Involved in MHC Class I Binding. J. Immunol. 168: 793-800 [Abstract] [Full Text]
Makrigiannis, A. P., Pau, A. T., Saleh, A., Winkler-Pickett, R., Ortaldo, J. R., Anderson, S. K. (2001). Class I MHC-Binding Characteristics of the 129/J Ly49 Repertoire. J. Immunol. 166: 5034-5043 [Abstract] [Full Text]
Van Beneden, K., Stevenaert, F., De Creus, A., Debacker, V., De Boever, J., Plum, J., Leclercq, G. (2001). Expression of Ly49E and CD94/NKG2 on Fetal and Adult NK Cells. J. Immunol. 166: 4302-4311 [Abstract] [Full Text]
Gays, F., Unnikrishnan, M., Shrestha, S., Fraser, K. P., Brown, A. R., Tristram, C. M. G., Chrzanowska-Lightowlers, Z. M. A., Brooks, C. G. (2000). The Mouse Tumor Cell Lines EL4 and RMA Display Mosaic Expression of NK-Related and Certain Other Surface Molecules and Appear to Have a Common Origin. J. Immunol. 164: 5094-5102 [Abstract] [Full Text]
Liu, J., Morris, M. A., Nguyen, P., George, T. C., Koulich, E., Lai, W. C., Schatzle, J. D., Kumar, V., Bennett, M. (2000). Ly49I NK Cell Receptor Transgene Inhibition of Rejection of H2b Mouse Bone Marrow Transplants. J. Immunol. 164: 1793-1799 [Abstract] [Full Text]
Korten, S., Wilk, E., Gessner, J. E., Meyer, D., Schmidt, R. E. (1999). Altered Donor and Recipient Ly49+ NK Cell Subsets in Allogeneic H-2d -> H-2b and H-2b -> H-2d Bone Marrow Chimeras. J. Immunol. 163: 5896-5905 [Abstract] [Full Text]
George, T. C., Ortaldo, J. R., Lemieux, S., Kumar, V., Bennett, M. (1999). Tolerance and Alloreactivity of the Ly49D Subset of Murine NK Cells. J. Immunol. 163: 1859-1867 [Abstract] [Full Text]
Lian, R. H., Li, Y., Kubota, S., Mager, D. L., Takei, F. (1999). Recognition of Class I MHC by NK Receptor Ly-49C: Identification of Critical Residues. J. Immunol. 162: 7271-7276 [Abstract] [Full Text]
Kase, A., Johansson, M. H., Olsson-Alheim, M. Y., Karre, K., Hoglund, P. (1998). External and Internal Calibration of the MHC Class I-Specific Receptor Ly49A on Murine Natural Killer Cells. J. Immunol. 161: 6133-6138 [Abstract] [Full Text]
Lian, R. H., Freeman, J. D., Mager, D. L., Takei, F. (1998). Role of Conserved Glycosylation Site Unique to Murine Class I MHC in Recognition by Ly-49 NK Cell Receptor. J. Immunol. 161: 2301-2306 [Abstract] [Full Text]
Chattergoon, M. A., Robinson, T. M., Boyer, J. D., Weiner, D. B. (1998). Specific Immune Induction Following DNA-Based Immunization Through In Vivo Transfection and Activation of Macrophages/Antigen-Presenting Cells. J. Immunol. 160: 5707-5718 [Abstract] [Full Text]
Mabee, C. L., McGuire, M. J., Thiele, D. L. (1998). Dipeptidyl Peptidase I and Granzyme A Are Coordinately Expressed During CD8+ T Cell Development and Differentiation. J. Immunol. 160: 5880-5885 [Abstract] [Full Text]
Ortaldo, J. R., Winkler-Pickett, R., Mason, A. T., Mason, L. H. (1998). The Ly-49 Family: Regulation of Cytotoxicity and Cytokine Production in Murine CD3+ Cells. J. Immunol. 160: 1158-1165 [Abstract] [Full Text]
Kung, S. K. P., Su, R.-C., Graham, J. J. K., Chamberlain, J. W., Miller, R. G. (1998). NK Cells from Human MHC Class I (HLA-B) Transgenic Mice Do Not Mediate Hybrid Resistance Killing Against Parental Nontransgenic cells. J. Immunol. 160: 674-680 [Abstract] [Full Text]
Raziuddin, A., Longo, D. L., Mason, L., Ortaldo, J. R., Bennett, M., Murphy, W. J. (1998). Differential Effects of the Rejection of Bone Marrow Allografts by the Depletion of Activating Versus Inhibiting Ly-49 Natural Killer Cell Subsets. J. Immunol. 160: 87-94 [Abstract] [Full Text]
Brennan, J., Lemieux, S., Freeman, J. D., Mager, D. L., Takei, F. (1996). Heterogeneity Among Ly-49C Natural Killer (NK) Cells: Characterization of Highly Related Receptors with Differing Functions and Expression Patterns. J. Exp. Med. 184: 2085-2090 [Abstract] [Full Text]
Mason, L.H., Anderson, S.K., Yokoyama, W.M., Smith, H.R.C., Winkler-Pickett, R., Ortaldo, J.R. (1996). The Ly-49D Receptor Activates Murine Natural Killer Cells. J. Exp. Med. 184: 2119-2128 [Abstract] [Full Text]
Hege, K. M., Cooke, K. S., Finer, M. H., Zsebo, K. M., Roberts, M. R. (1996). Systemic T Cell-independent Tumor Immunity after Transplantation of Universal Receptor-modified Bone Marrow into SCID Mice. J. Exp. Med. 184: 2261-2270 [Abstract] [Full Text]
Brennan, J., Takei, F., Wong, S., Mager, D. L. (1995). Carbohydrate Recognition by a Natural Killer Cell Receptor, Ly-49C. J. Biol. Chem. 270: 9691-9694 [Abstract] [Full Text]
Wang, J., Whitman, M. C., Natarajan, K., Tormo, J., Mariuzza, R. A., Margulies, D. H. (2002). Binding of the Natural Killer Cell Inhibitory Receptor Ly49A to Its Major Histocompatibility Complex Class I Ligand. CRUCIAL CONTACTS INCLUDE BOTH H-2Dd AND beta 2-MICROGLOBULIN. J. Biol. Chem. 277: 1433-1442 [Abstract] [Full Text]