Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related

doi:10.1084/jem.169.5.1853

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Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related

T Noma, H Nakakubo, M Sugita, S Kumagai, M Maeda, A Shimizu and T Honjo
Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan.

We have analyzed expression patterns of 7 lymphokine mRNAs by Northern blot analyses in 19 different human T cell clones derived from patients with adult T cell leukemia. However, we were not able to reveal particular combinations of lymphokine production that allowed classification of human T cells. Especially, four clonally related leukemic lines that were established independently from the same patient with adult T cell leukemia expressed different combinations of lymphokine mRNAs, indicating that the expression of various lymphokines is not fixed but rather variable even among progenies of a single T cell clone.
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