Human monocytes can produce tissue-type plasminogen activator

doi:10.1084/jem.169.4.1509

3rd Skeletal Biology and Medicine Symposium

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Human monocytes can produce tissue-type plasminogen activator

PH Hart, GF Vitti, DR Burgess, DK Singleton and JA Hamilton
Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Australia.

Evidence has previously been presented that monocytes and macrophages produce urokinase-type plasminogen activator. We have shown for the first time that human monocytes, when stimulated appropriately in vitro, can produce tissue type-plasminogen activator (t-PA) of 70 kD. Detection of t-PA mRNA was consistent with the biochemical and immunological characterization of t-PA produced by human monocytes.
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