A subset of memory CD4+ helper T lymphocytes identified by expression of Pgp-1

doi:10.1084/jem.169.4.1461

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A subset of memory CD4+ helper T lymphocytes identified by expression of Pgp-1

K Butterfield, CG Fathman and RC Budd
Department of Medicine, Stanford University School of Medicine, California 94305.

The Pgp-1 glycoprotein (Ly-24 antigen) is acquired by mature murine T lymphocytes at the time of primary antigen stimulation Pgp-1 was previously shown to be a useful cell surface marker for distinguishing antigen-specific memory CD8+ T lymphocytes after immunization. Here we demonstrate that this observation extends to CD4+ T lymphocytes. Antigen-specific CD4+ T cells in mice immunized with sperm whale myoglobin or keyhole limpet hemocyanin were contained nearly exclusively in the minor Pgp-1+ subset.
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