A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes

doi:10.1084/jem.169.4.1421

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A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes

H Tsubota, CI Lord, DI Watkins, C Morimoto and NL Letvin
Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772.

CD8+ (suppressor/cytotoxic) lymphocytes block replication of HIV-1 or the simian immunodeficiency virus of macaques (SIVmac) in PBL of infected individuals. We now show that these CD8+ lymphocytes undergo clonal expansion in vivo after AIDS virus infection of the individual, suggesting they may be antigen-specific T cells. These CD8+ cells block replication of virus in autologous but not MHC class I-mismatched PBL. The inhibitory lymphocytes express the integrin family molecule 4B4 and the CTL-associated S6F1 epitope of LFA-1. Finally, physical contact is required for the CD8+ lymphocyte-mediated inhibition of AIDS virus replication, since this inhibitory function is blocked by anti-LFA-1 and anti-CD8 mAbs. These studies suggest that the cell that inhibits AIDS virus replication in PBL of infected individuals is a CTL.
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Loffredo, J. T., Burwitz, B. J., Rakasz, E. G., Spencer, S. P., Stephany, J. J., Giraldo Vela, J. P., Martin, S. R., Reed, J., Piaskowski, S. M., Furlott, J., Weisgrau, K. L., Rodrigues, D. S., Soma, T., Napoe, G., Friedrich, T. C., Wilson, N. A., Kallas, E. G., Watkins, D. I. (2007). The Antiviral Efficacy of Simian Immunodeficiency Virus-Specific CD8+ T Cells Is Unrelated to Epitope Specificity and Is Abrogated by Viral Escape. J. Virol. 81: 2624-2634 [Abstract] [Full Text]
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Zhang, H., Fayad, R., Wang, X., Quinn, D., Qiao, L. (2004). Human Immunodeficiency Virus Type 1 Gag-Specific Mucosal Immunity after Oral Immunization with Papillomavirus Pseudoviruses Encoding Gag. J. Virol. 78: 10249-10257 [Abstract] [Full Text]
Williamson, S. (2003). Adaptation in the env Gene of HIV-1 and Evolutionary Theories of Disease Progression. Mol Biol Evol 20: 1318-1325 [Abstract] [Full Text]
Sindhu, S. T. A. K., Ahmad, R., Morisset, R., Ahmad, A., Menezes, J. (2003). Peripheral Blood Cytotoxic {gamma}{delta} T Lymphocytes from Patients with Human Immunodeficiency Virus Type 1 Infection and AIDS Lyse Uninfected CD4+ T Cells, and Their Cytocidal Potential Correlates with Viral Load. J. Virol. 77: 1848-1855 [Abstract] [Full Text]
Ross, H. A., Rodrigo, A. G. (2002). Immune-Mediated Positive Selection Drives Human Immunodeficiency Virus Type 1 Molecular Variation and Predicts Disease Duration. J. Virol. 76: 11715-11720 [Abstract] [Full Text]
Ansari, A. A., Mayne, A. E., Sundstrom, J. B., Bostik, P., Grimm, B., Altman, J. D., Villinger, F. (2002). Administration of Recombinant Rhesus Interleukin-12 during Acute Simian Immunodeficiency Virus (SIV) Infection Leads to Decreased Viral Loads Associated with Prolonged Survival in SIVmac251-Infected Rhesus Macaques. J. Virol. 76: 1731-1743 [Abstract] [Full Text]
Chang, T. L.-Y., Mosoian, A., Pine, R., Klotman, M. E., Moore, J. P. (2002). A Soluble Factor(s) Secreted from CD8+ T Lymphocytes Inhibits Human Immunodeficiency Virus Type 1 Replication through STAT1 Activation. J. Virol. 76: 569-581 [Abstract] [Full Text]
Chen, Z. W., Shen, Y., Zhou, D., Simon, M., Kou, Z., Lee-Parritz, D., Shen, L., Sehgal, P., Letvin, N. L. (2001). In Vivo T-Lymphocyte Activation and Transient Reduction of Viral Replication in Macaques Infected with Simian Immunodeficiency Virus. J. Virol. 75: 4713-4720 [Abstract] [Full Text]
Allen, T. M., Mothé, B. R., Sidney, J., Jing, P., Dzuris, J. L., Liebl, M. E., Vogel, T. U., O'Connor, D. H., Wang, X., Wussow, M. C., Thomson, J. A., Altman, J. D., Watkins, D. I., Sette, A. (2001). CD8+ Lymphocytes from Simian Immunodeficiency Virus-Infected Rhesus Macaques Recognize 14 Different Epitopes Bound by the Major Histocompatibility Complex Class I Molecule Mamu-A*01: Implications for Vaccine Design and Testing. J. Virol. 75: 738-749 [Abstract] [Full Text]
Chun, T.-W., Justement, J. S., Moir, S., Hallahan, C. W., Ehler, L. A., Liu, S., McLaughlin, M., Dybul, M., Mican, J. M., Fauci, A. S. (2001). Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: Implications for the development of therapeutic strategies. Proc. Natl. Acad. Sci. USA 98: 253-258 [Abstract] [Full Text]
Cocchi, F., DeVico, A. L., Yarchoan, R., Redfield, R., Cleghorn, F., Blattner, W. A., Garzino-Demo, A., Colombini-Hatch, S., Margolis, D., Gallo, R. C. (2000). Higher macrophage inflammatory protein (MIP)-1alpha and MIP-1beta levels from CD8+ T cells are associated with asymptomatic HIV-1 infection. Proc. Natl. Acad. Sci. USA 10.1073/pnas.240469997v1 [Abstract] [Full Text]
Le Borgne, S., Février, M., Callebaut, C., Lee, S. P., Rivière, Y. (2000). CD8+-Cell Antiviral Factor Activity Is Not Restricted to Human Immunodeficiency Virus (HIV)-Specific T Cells and Can Block HIV Replication after Initiation of Reverse Transcription. J. Virol. 74: 4456-4464 [Abstract] [Full Text]
Furchner, M., Erickson, A. L., Allen, T., Watkins, D. I., Sette, A., Johnson, P. R., Walker, C. M. (1999). The Simian Immunodeficiency Virus Envelope Glycoprotein Contains Two Epitopes Presented by the Mamu-A*01 Class I Molecule. J. Virol. 73: 8035-8039 [Abstract] [Full Text]
Balla-Jhagjhoorsingh, S. S., Koopman, G., Mooij, P., Haaksma, T. G. M., Teeuwsen, V. J. P., Bontrop, R. E., Heeney, J. L. (1999). Conserved CTL Epitopes Shared Between HIV-Infected Human Long-Term Survivors and Chimpanzees. J. Immunol. 162: 2308-2314 [Abstract] [Full Text]
Kuroda, M. J., Schmitz, J. E., Charini, W. A., Nickerson, C. E., Lord, C. I., Forman, M. A., Letvin, N. L. (1999). Comparative Analysis of Cytotoxic T Lymphocytes in Lymph Nodes and Peripheral Blood of Simian Immunodeficiency Virus-Infected Rhesus Monkeys. J. Virol. 73: 1573-1579 [Abstract] [Full Text]
Mackewicz, C. E., Garovoy, M. R., Levy, J. A. (1998). HLA Compatibility Requirements for CD8+-T-Cell-Mediated Suppression of Human Immunodeficiency Virus Replication. J. Virol. 72: 10165-10170 [Abstract] [Full Text]
Fehniger, T. A., Herbein, G., Yu, H., Para, M. I., Bernstein, Z. P., O'Brien, W. A., Caligiuri, M. A. (1998). Natural Killer Cells from HIV-1+ Patients Produce C-C Chemokines and Inhibit HIV-1 Infection. J. Immunol. 161: 6433-6438 [Abstract] [Full Text]
Gauduin, M.-C., Glickman, R. L., Means, R., Johnson, R. P. (1998). Inhibition of Simian Immunodeficiency Virus (SIV) Replication by CD8+ T Lymphocytes from Macaques Immunized with Live Attenuated SIV. J. Virol. 72: 6315-6324 [Abstract] [Full Text]
Van Baalen, C. A., Schutten, M., Huisman, R. C., Boers, P. H.�M., Gruters, R. A., Osterhaus, A. D.�M.�E. (1998). Kinetics of Antiviral Activity by Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes (CTL) and Rapid Selection of CTL Escape Virus In Vitro. J. Virol. 72: 6851-6857 [Abstract] [Full Text]
Schmitz, J. E., Forman, M. A., Lifton, M. A., Concepcion, O. Jr, Reimann, K. A., Crumpacker, C. S., Daley, J. F., Gelman, R. S., Letvin, N. L. (1998). Expression of the CD8alpha beta -Heterodimer on CD8+ T Lymphocytes in Peripheral Blood Lymphocytes of Human Immunodeficiency Virus- and Human Immunodeficiency Virus+ Individuals. Blood 92: 198-206 [Abstract] [Full Text]
Letvin, N. L. (1998). Progress in the Development of an HIV-1 Vaccine. Science 280: 1875-1880 [Abstract] [Full Text]
Kuroda, M. J., Schmitz, J. E., Barouch, D. H., Craiu, A., Allen, T. M., Sette, A., Watkins, D. I., Forman, M. A., Letvin, N. L. (1998). Analysis of Gag-specific Cytotoxic T Lymphocytes in Simian Immunodeficiency Virus-infected Rhesus Monkeys by Cell Staining with a Tetrameric Major Histocompatibility Complex Class I-Peptide Complex. J. Exp. Med. 187: 1373-1381 [Abstract] [Full Text]
Mortara, L., Letourneur, F., Gras-masse, H., Venet, A., Guillet, J.-G., Bourgault-Villada, I. (1998). Selection of Virus Variants and Emergence of Virus Escape Mutants after Immunization with an Epitope Vaccine. J. Virol. 72: 1403-1410 [Abstract] [Full Text]
Moriuchi, H., Moriuchi, M., Combadiere, C., Murphy, P.�M., Fauci, A.�S. (1996). CD8+ T-cell-derived soluble factor(s), but not beta -chemokines RANTES, MIP-1alpha , and MIP-1beta , suppress HIV-1 replication in�monocyte/macrophages. Proc. Natl. Acad. Sci. USA 93: 15341-15345 [Abstract] [Full Text]
Letvin, N. L. (1993). Vaccines against Human Immunodeficiency Virus -- Progress and Prospects. NEJM 329: 1400-1405 [Full Text]
Shen, L, Chen, Z., Miller, M., Stallard, V, Mazzara, G., Panicali, D., Letvin, N. (1991). Recombinant virus vaccine-induced SIV-specific CD8+ cytotoxic T lymphocytes. Science 252: 440-443 [Abstract]
Takahashi, H, Merli, S, Putney, S., Houghten, R, Moss, B, Germain, R., Berzofsky, J. (1989). A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160. Science 246: 118-121 [Abstract]
Cocchi, F., DeVico, A. L., Yarchoan, R., Redfield, R., Cleghorn, F., Blattner, W. A., Garzino-Demo, A., Colombini-Hatch, S., Margolis, D., Gallo, R. C. (2000). Higher macrophage inflammatory protein (MIP)-1alpha and MIP-1beta levels from CD8+ T cells are associated with asymptomatic HIV-1 infection. Proc. Natl. Acad. Sci. USA 97: 13812-13817 [Abstract] [Full Text]