Active and latent forms of transforming growth factor beta activity in synovial effusions

doi:10.1084/jem.169.1.291

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Active and latent forms of transforming growth factor beta activity in synovial effusions

R Fava, N Olsen, J Keski-Oja, H Moses and T Pincus
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.

We have evaluated the possible involvement of TGF-beta in rheumatoid arthritis by assay of 16 cell-free synovial fluids for the presence of its active and "latent" forms. Evidence has been obtained for TGF-beta- like activity in synovial effusions by four criteria: (a) TGF-beta receptor competition, (b) soft-agar colony formation of AKR-2B and NRK- 49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form.
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