The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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Journal of Experimental Medicine, Vol 169, 285-290, Copyright © 1989 by Rockefeller University Press

ARTICLES

Role of the thymus in natural tolerance to an autologous protein antigen

M Boguniewicz, GH Sunshine and Y Borel
Division of Immunology, Children's Hospital, Boston, Massachusetts.

C5-deficient mice grafted with thymus from C5-sufficient donors and immunized with C5 failed to make humoral antibody to C5, suggesting that the transfer of thymus had induced tolerance. Irradiated C5- deficient hosts repopulated with lymphoid cells from thymectomized C5- deficient mice grafted with C5-sufficient thymus also failed to respond to immunization with C5, thus showing that the state of tolerance can be adoptively transferred. These results demonstrate that natural tolerance to self-protein antigen is "learned" in the thymus.
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