Journal of Experimental Medicine, Vol 168, 2379-2384, Copyright © 1988 by Rockefeller University Press

ARTICLES

Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone

LA Matis, A Ezquerra and JE Coligan
Division of Biochemistry and Biophysics, Food and Drug Administration, Bethesda, Maryland.

A cytochrome c-specific, MHC-restricted T cell clone with two complete rearrangements of the same V beta 1 gene element was shown to express two different TCR alpha/beta heterodimers. Antipeptide antisera specific for TCR C beta 1 and C beta 2 peptides each immunoprecipitated distinct disulfide-linked cell surface heterodimers. The clone was derived from immunized allogeneic chimeric mice, and displayed multiple Ia specificities, including the ability to recognize antigen in association with both I-Ek and I-Es Ia molecules, as well as alloreactivity to the I-Eb molecule. It will be important to determine whether each receptor contributes independently to the overall specificity of the clone.
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This article has been cited by other articles:

• Turka, L., Schatz, D., Oettinger, M., Chun, J., Gorka, C, Lee, K, McCormack, W., Thompson, C. (1991). Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science 253: 778-781 [Abstract]  

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