The Journal of Experimental Medicine
Keystone Symposia
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Journal of Experimental Medicine, Vol 168, 2355-2360, Copyright © 1988 by Rockefeller University Press

ARTICLES

Induction of lymphokine-activated killer-like cells by cancer chemotherapy

T Kiyohara, K Taniguchi, S Kubota, S Koga, T Sakuragi and Y Saitoh
Department of Pathology, Nagasaki University, Japan.

Natural cell-mediated cytotoxicity against NK-resistant target tumor cells was found in the peripheral blood of tumor-bearing patients approximately 1 mo after combined chemotherapy. The recognition specificity of these effector cells was broad and had no restriction. From the experiments of negative selection with mAbs and complements, these newly developed killer cells after chemotherapy were thought to be LAK-like cells. Contribution of these LAK-like cells to the mechanism of action of anticancer drugs remains to be clarified.
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