The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 168, 1395-1402, Copyright © 1988 by Rockefeller University Press

ARTICLES

Keratinocyte growth regulation by the products of immune cells

GE Hancock, G Kaplan and ZA Cohn
Rockefeller University, New York, New York 10021.

We describe a bioassay that allows the in vitro investigation of the stimulatory and suppressive factors derived from immune cells in short- term cultures of human keratinocytes. In agreement with other assays, epidermal growth factor is not mitogenic for human keratinocytes. Supernatant fluid from human PBMC stimulated with Con A, from allo- MLRs, as well as supernatants from nonstimulated PBMC, possess growth- promoting molecules. Our results show that both activated and nonactivated T cells release growth factors. Suppressive molecules are produced preferentially by monocyte cultures. Two T cell products, IFN- gamma and transforming growth factor beta are both inhibitory for keratinocyte proliferation. Two other T cell products, IL-3 and GM-CSF, stimulate keratinocyte proliferation at nanogram concentrations. These results suggest the existence of regulatory circuits between the T cells of a dermal inflammatory infiltrate and the overlying epidermal keratinocytes. This may determine the fine control of epidermal proliferation and turnover leading either to enhanced wound repair or skin pathology.
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