Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor

doi:10.1084/jem.167.5.1708

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Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor

R Bertini, M Bianchi and P Ghezzi
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.

To clarify the possible role of TNF and IL-1 in endotoxic shock, the lethality of rTNF (human and murine) and IL-1 in adrenalectomized mice was studied. Adrenalectomy, which has long been known to increase the susceptibility to endotoxin, rendered mice susceptible to TNF and IL-1 in terms of mortality. The lethality of endotoxin, TNF, or IL-1 was totally prevented by pretreatment with dexamethasone (minimal effective dose, 0.3 mg/Kg) but not by ibuprofen (10 mg/Kg).
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