The Journal of Experimental Medicine
ThymUS '08
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Journal of Experimental Medicine, Vol 167, 682-687, Copyright © 1988 by Rockefeller University Press

ARTICLES

Chromosomal translocation involving the beta T cell receptor gene in acute leukemia

ML Cleary, JD Mellentin, J Spies and SD Smith
Department of Pathology, Stanford University School of Medicine, California 94305.

DNA spanning a t(7;19) chromosomal translocation breakpoint was isolated from the human T cell line SUP-T7 established from an acute lymphoblastic leukemia. Nucleotide sequence analysis showed that the point of crossover on chromosome 7 occurred immediately adjacent to joining segment J beta 1.1 within the TCR-beta gene, suggesting that this translocation resulted from an error in TCR gene rearrangement. On chromosome 19, the translocation occurred within a previously uncharacterized transcriptional unit for which we propose the name lyl- 1. An approximately 1.5-kb RNA is transcribed from this gene in a wide variety of hematolymphoid cell lines. The t(7;19) results in truncation of the lyl-1 gene and production of abnormal-sized RNAs, suggesting a role for lyl-1 in the pathogenesis of this leukemia.
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