Independent association of T cell receptor beta and gamma chains with CD3 in the same cell

doi:10.1084/jem.166.2.595

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Independent association of T cell receptor beta and gamma chains with CD3 in the same cell

F Koning, WL Maloy, D Cohen and JE Coligan

We have demonstrated that the PEER cell line, which expresses a CD3- associated TCR gamma chain on the cell surface, synthesizes TCR beta chain intracellularly. A percentage of this TCR beta chain associates with the CD3 complex intracellularly. These results indicate that TCR beta and gamma chains can be synthesized by one cell line, and that these chains can independently associate with the CD3 complex. However, the results argue against the formation of TCR beta gamma chain complexes in this cell line.
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