Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer

doi:10.1084/jem.166.1.219

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Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer

PW Kantoff, AP Gillio, JR McLachlin, C Bordignon, MA Eglitis, NA Kernan, RC Moen, DB Kohn, SF Yu and E Karson

Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals. Several monkeys fully reconstituted and were shown to express the h-ADA and neor genes at low levels in their recirculating hematopoietic cells for short periods of time.
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