Journal of Experimental Medicine, Vol 165, 1430-1435, Copyright © 1987 by Rockefeller University Press

ARTICLES

A major immunogen in Schistosoma mansoni infections is homologous to the heat-shock protein Hsp70

R Hedstrom, J Culpepper, RA Harrison, N Agabian and G Newport

A 70,000 mol wt protein of Schistosoma mansoni was shown to be a major immunogen that invariably elicited an antibody response in infected humans. The universality of the response to this abundant antigen was confirmed in experimental animals and included the antibody response associated with the protective irradiated cercarial vaccine. We identified the 70,000 mol wt antigen as an S. mansoni homologue of the major eukaryotic heat-shock protein hsp70 by DNA sequence analysis of a cDNA insert from a lambda gt11 clone expressing the antigen and located the immunodominant epitope near the COOH-terminus of the molecule. The antigenic relationship of hsp70 to schistosome infections suggested an important role for this protein in parasite development and pathogenesis.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Rico, A. I., Del Real, G., Soto, M., Quijada, L., Martinez-A., C., Alonso, C., Requena, J. M. (1998). Characterization of the Immunostimulatory Properties of Leishmania infantum HSP70 by Fusion to the Escherichia coli Maltose-Binding Protein in Normal and nu/nu BALB/c Mice. Infect. Immun. 66: 347-352 [Abstract] [Full Text]  
• Suzue, K., Zhou, X., Eisen, H. N., Young, R. A. (1997). Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway. Proc. Natl. Acad. Sci. USA 94: 13146-13151 [Abstract] [Full Text]  
• Buchmeier, N., Heffron, F (1990). Induction of Salmonella stress proteins upon infection of macrophages. Science 248: 730-732 [Abstract]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS