The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration

doi:10.1084/jem.165.4.1218

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Perry, V. H.
	Articles by Gordon, S.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Perry, V. H.
	Articles by Gordon, S.


Social Bookmarking

	What's this?

ARTICLES

The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration

VH Perry, MC Brown and S Gordon

Using mAbs and immunocytochemistry we have examined the response of macrophages (M phi) after crush injury to the sciatic or optic nerve in the mouse and rat. We have established that large numbers of M phi enter peripheral nerves containing degenerating axons; the M phi are localized to the portion containing damaged axons, and they phagocytose myelin. The period of recruitment of the M phi in the peripheral nerve is before and during the period of maximal proliferation of the Schwann cells. In contrast, the degenerating optic nerve attracts few M phi, and the removal of myelin is much slower. These results show the clearly different responses of M phi to damage in the central and peripheral nervous systems, and suggest that M phi may be an important component of subsequent repair as well as myelin degradation.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Wall, P. L., McCluskey, L. P. (2008). Rapid Changes in Gustatory Function Induced by Contralateral Nerve Injury and Sodium Depletion. Chem Senses 33: 125-135 [Abstract] [Full Text]
Thacker, M. A., Clark, A. K., Marchand, F., McMahon, S. B. (2007). Pathophysiology of Peripheral Neuropathic Pain: Immune Cells and Molecules. Anesth. Analg. 105: 838-847 [Abstract] [Full Text]
Namikawa, K., Okamoto, T., Suzuki, A., Konishi, H., Kiyama, H. (2006). Pancreatitis-associated protein-III is a novel macrophage chemoattractant implicated in nerve regeneration.. J. Neurosci. 26: 7460-7467 [Abstract] [Full Text]
Sharghi-Namini, S., Turmaine, M., Meier, C., Sahni, V., Umehara, F., Jessen, K. R., Mirsky, R. (2006). The structural and functional integrity of peripheral nerves depends on the glial-derived signal desert hedgehog.. J. Neurosci. 26: 6364-6376 [Abstract] [Full Text]
Wong, A. M.F., McReelis, K., Sharpe, J. A. (2006). Saccade dynamics in peripheral vs central sixth nerve palsies. Neurology 66: 1390-1398 [Abstract] [Full Text]
Liu, X., Hawkes, E., Ishimaru, T., Tran, T., Sretavan, D. W. (2006). EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury.. J. Neurosci. 26: 3087-3101 [Abstract] [Full Text]
Hall, S. (2005). The response to injury in the peripheral nervous system. J Bone Joint Surg Br 87-B: 1309-1319 [Full Text]
Perrin, F. E., Lacroix, S., Aviles-Trigueros, M., David, S. (2005). Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1{alpha} and interleukin-1{beta} in Wallerian degeneration. Brain 128: 854-866 [Abstract] [Full Text]
Bendszus, M., Stoll, G. (2003). Caught in the Act: In Vivo Mapping of Macrophage Infiltration in Nerve Injury by Magnetic Resonance Imaging. J. Neurosci. 23: 10892-10896 [Abstract] [Full Text]
Tofaris, G. K., Patterson, P. H., Jessen, K. R., Mirsky, R. (2002). Denervated Schwann Cells Attract Macrophages by Secretion of Leukemia Inhibitory Factor (LIF) and Monocyte Chemoattractant Protein-1 in a Process Regulated by Interleukin-6 and LIF. J. Neurosci. 22: 6696-6703 [Abstract] [Full Text]
Shamash, S., Reichert, F., Rotshenker, S. (2002). The Cytokine Network of Wallerian Degeneration: Tumor Necrosis Factor-alpha , Interleukin-1alpha , and Interleukin-1beta. J. Neurosci. 22: 3052-3060 [Abstract] [Full Text]
Milner, R., Campbell, I. L. (2002). Cytokines Regulate Microglial Adhesion to Laminin and Astrocyte Extracellular Matrix via Protein Kinase C-Dependent Activation of the alpha 6beta 1 Integrin. J. Neurosci. 22: 1562-1572 [Abstract] [Full Text]
Duerstock, B. S., Borgens, R. B. (2002). Three-dimensional morphometry of spinal cord injury following polyethylene glycol treatment. J. Exp. Biol. 205: 13-24 [Abstract] [Full Text]
Ousman, S. S., David, S. (2001). MIP-1{alpha}, MCP-1, GM-CSF, and TNF-{alpha} Control the Immune Cell Response That Mediates Rapid Phagocytosis of Myelin from the Adult Mouse Spinal Cord. J. Neurosci. 21: 4649-4656 [Abstract] [Full Text]
Kuhlmann, T., Bitsch, A., Stadelmann, C., Siebert, H., Bruck, W. (2001). Macrophages Are Eliminated from the Injured Peripheral Nerve via Local Apoptosis and Circulation to Regional Lymph Nodes and the Spleen. J. Neurosci. 21: 3401-3408 [Abstract] [Full Text]
Ramer, M. S., Duraisingam, I., Priestley, J. V., McMahon, S. B. (2001). Two-Tiered Inhibition of Axon Regeneration at the Dorsal Root Entry Zone. J. Neurosci. 21: 2651-2660 [Abstract] [Full Text]
Leskovar, A, Moriarty, L., Turek, J., Schoenlein, I., Borgens, R. (2000). The macrophage in acute neural injury: changes in cell numbers over time and levels of cytokine production in mammalian central and peripheral nervous systems. J. Exp. Biol. 203: 1783-1795 [Abstract]
MOALEM, G., MONSONEGO, A., SHANI, Y., COHEN, I. R., SCHWARTZ, M. (1999). Differential T cell response in central and peripheral nerve injury: connection with immune privilege. FASEB J. 13: 1207-1217 [Abstract] [Full Text]
FRIEDMANN, I., FABER-ELMAN, A., YOLES, E., SCHWARTZ, M. (1999). Injury-induced gelatinase and thrombin-like activities in regenerating and nonregenerating nervous systems. FASEB J. 13: 533-543 [Abstract] [Full Text]
Becker, C. G., Becker, T., Meyer, R. L., Schachner, M. (1999). Tenascin-R Inhibits the Growth of Optic Fibers In Vitro But Is Rapidly Eliminated during Nerve Regeneration in the Salamander Pleurodeles waltl. J. Neurosci. 19: 813-827 [Abstract] [Full Text]
Monsonego, A., Mizrahi, T., Eitan, S., Moalem, G., Bárdos, H., Ádány, R., Schwartz, M. (1998). Factor XIIIa as a nerve-associated transglutaminase. FASEB J. 12: 1163-1171 [Abstract] [Full Text]
de Chaves, E. I.�P., Rusinol, A. E., Vance, D. E., Campenot, R. B., Vance, J. E. (1997). Role of Lipoproteins in the Delivery of Lipids to Axons during Axonal Regeneration. J. Biol. Chem. 272: 30766-30773 [Abstract] [Full Text]
Bittigau, P., Ikonomidou, C. (1997). Topical Review: Glutamate in Neurologic Diseases. J Child Neurol 12: 471-485 [Abstract]
Monsonego, A., Shani, Y., Friedmann, I., Paas, Y., Eizenberg, O., Schwartz, M. (1997). Expression of GTP-dependent and GTP-independent Tissue-type Transglutaminase in Cytokine-treated Rat Brain Astrocytes. J. Biol. Chem. 272: 3724-3732 [Abstract] [Full Text]
Cecchini, M., Dominguez, M., Mocci, S, Wetterwald, A, Felix, R, Fleisch, H, Chisholm, O, Hofstetter, W, Pollard, J., Stanley, E. (1994). Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse. Development 120: 1357-1372 [Abstract]