The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 164, 2083-2088, Copyright © 1986 by Rockefeller University Press

ARTICLES

Gene correction in the evolution of the T cell receptor beta chain

E Jouvin-Marche, M Heller and S Rudikoff

Mutational mechanisms operating at the T cell receptor beta chain locus have been examined by comparison of the CT beta 1 and CT beta 2 gene sequences from Mus pahari, believed to be the oldest living species in the genus Mus, with those of inbred mice. Results indicate that a gene correction event independent of that suggested to have occurred in inbred mice has homogenized the M. pahari CT beta exon 1 sequences, minimizing diversity in this region of the molecule. These observations suggest that correction events such as gene conversion may occur frequently, even in pauci-gene families with as few as two members, and therefore play a significant role in gene diversification or homogenization of small as well as large gene families.
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