Journal of Experimental Medicine, Vol 164, 383-392, Copyright © 1986 by Rockefeller University Press
Terminal maturation of resting B cells by proliferation-independent B cells differentiation factors
L Mayer
Using response to four different BCDF preparations as a model of B cell
maturation, we have shown that induction of B cell proliferation abrogates
terminal maturation of these cells. In fact, response to some BCDFs can
occur in the presence of inhibitors of DNA replication, suggesting that
there are proliferation-independent as well as proliferation-dependent
BCDFs. These findings cannot be explained by changes in the kinetics of the
BCDF response, nor can they be reversed by repletion of media or changing
cell densities. Proliferation- independent BCDFs appear to exert their
effects on dense, resting 4F2- B cells rather than more activated B cells.
This is in contrast to B cell differentiation signals of IL-2 alone or SAC
and IL-2 in concert. These data suggest that the current models of B cell
activation and maturation may require some reorganization, relegating the
proliferative phase of B cell maturation to a lesser role. In addition,
evidence is provided for the fact that the resting B cell may have the full
complement of receptors for BCDF as well as BCGF and BCPF and may help
account for the inherent nonspecificity of the immune response.
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