Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor

doi:10.1084/jem.163.6.1595

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Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor

RL Nachman, KA Hajjar, RL Silverstein and CA Dinarello

Human endothelial cells activated with IL-1 express a surface membrane- oriented procoagulant generating system characterized by increased tissue factor synthesis and decreased thrombomodulin activity. We now report that IL-1 also stimulates endothelial cell synthesis of plasminogen activator inhibitor. This array of IL-1-induced activities shifts the balance at the endothelial cell surface to a prothrombotic influence and may reflect an early response of the blood vessel wall to injury.
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