Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts

doi:10.1084/jem.162.6.2163

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Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts

JM Dayer, B Beutler and A Cerami

Cachectin/TNF (tumor necrosis factor), an endotoxin-induced murine macrophage hormone implicated in the pathogenesis of cachexia and shock, has been found capable of stimulating collagenase and prostaglandin E2 (PGE2) production by isolated human synovial cells and dermal fibroblasts. This bioactivity associated with cachectin is comparable to that observed with the monokine interleukin 1 (IL-1), previously suggested as the major mediator of proteolysis. The ability of cachectin/TNF to stimulate collagenase and PGE2 production suggests that it may play a role in tissue destruction and remodelling, as these processes occur in inflammatory diseases.
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Zer, C., Sachs, G., Shin, J. M. (2007). Identification of genomic targets downstream of p38 mitogen-activated protein kinase pathway mediating tumor necrosis factor-{alpha} signaling. Physiol. Genomics 31: 343-351 [Abstract] [Full Text]
Jennings-Gee, J. E., Tsuji, Y., Pietsch, E. C., Moran, E., Mymryk, J. S., Torti, F. M., Torti, S. V. (2006). Coordinate Inhibition of Cytokine-mediated Induction of Ferritin H, Manganese Superoxide Dismutase, and Interleukin-6 by the Adenovirus E1A Oncogene. J. Biol. Chem. 281: 16428-16435 [Abstract] [Full Text]
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O'Reilly, K. M. A., Phipps, R. P., Thatcher, T. H., Graf, B. A., Van Kirk, J., Sime, P. J. (2005). Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 288: L1010-L1016 [Abstract] [Full Text]
Yoo, S.-A., Bae, D.-G., Ryoo, J.-W., Kim, H.-R., Park, G.-S., Cho, C.-S., Chae, C.-B., Kim, W.-U. (2005). Arginine-Rich Anti-Vascular Endothelial Growth Factor (Anti-VEGF) Hexapeptide Inhibits Collagen-Induced Arthritis and VEGF-Stimulated Productions of TNF-{alpha} and IL-6 by Human Monocytes. J. Immunol. 174: 5846-5855 [Abstract] [Full Text]
Na, H.-J., Lee, S.-J., Kang, Y.-C., Cho, Y.-L., Nam, W.-D., Kim, P. K. M., Ha, K.-S., Chung, H.-T., Lee, H., Kwon, Y.-G., Koh, J. S., Kim, Y.-M. (2004). Inhibition of Farnesyltransferase Prevents Collagen-Induced Arthritis by Down-Regulation of Inflammatory Gene Expression through Suppression of p21ras-Dependent NF-{kappa}B Activation. J. Immunol. 173: 1276-1283 [Abstract] [Full Text]
Mease, P (2004). TNF{alpha} therapy in psoriatic arthritis and psoriasis. Ann Rheum Dis 63: 755-758 [Full Text]
Tanaka, M., Ozaki, S., Kawabata, D., Kishimura, M., Osakada, F., Okubo, M., Murakami, M., Nakao, K., Mimori, T. (2003). Potential preventive effects of follistatin-related protein/TSC-36 on joint destruction and antagonistic modulation of its autoantibodies in rheumatoid arthritis. Int Immunol 15: 71-77 [Abstract] [Full Text]
Gurlek, A., Pittelkow, M. R., Kumar, R. (2002). Modulation of Growth Factor/Cytokine Synthesis and Signaling by 1{alpha},25-Dihydroxyvitamin D3: Implications in Cell Growth and Differentiation. Endocr. Rev. 23: 763-786 [Abstract] [Full Text]
Dayer, J.-M., Krane, S. M. (2002). Anti-TNF-{alpha} Therapy for Ankylosing Spondylitis -- A Specific or Nonspecific Treatment?. NEJM 346: 1399-1400 [Full Text]
Mease, P J (2002). Tumour necrosis factor (TNF) in psoriatic arthritis: pathophysiology and treatment with TNF inhibitors. Ann Rheum Dis 61: 298-304 [Abstract] [Full Text]
Drynda, S, Kuhne, C, Kekow, J (2002). Soluble tumour necrosis factor receptor treatment does not affect raised transforming growth factor {beta} levels in rheumatoid arthritis. Ann Rheum Dis 61: 254-256 [Abstract] [Full Text]
Sivasubramanian, N., Coker, M. L., Kurrelmeyer, K. M., MacLellan, W. R., DeMayo, F. J., Spinale, F. G., Mann, D. L. (2001). Left Ventricular Remodeling in Transgenic Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor. Circulation 104: 826-831 [Abstract] [Full Text]
Ferrari-Lacraz, S., Nicod, L. P., Chicheportiche, R., Welgus, H. G., Dayer, J.-M. (2001). Human Lung Tissue Macrophages, but not Alveolar Macrophages, Express Matrix Metalloproteinases after Direct Contact with Activated T Lymphocytes. Am. J. Respir. Cell Mol. Bio. 24: 442-451 [Abstract] [Full Text]
Kieseier, B. C., Schneider, C., Clements, J. M., Gearing, A. J. H., Gold, R., Toyka, K. V., Hartung, H.-P. (2001). Expression of specific matrix metalloproteinases in inflammatory myopathies. Brain 124: 341-351 [Abstract] [Full Text]
ORTIZ, L. A., LASKY, J., GOZAL, E., RUIZ, V., LUNGARELLA, G., CAVARRA, E., BRODY, A. R., FRIEDMAN, M., PARDO, A., SELMAN, M. (2001). Tumor Necrosis Factor Receptor Deficiency Alters Matrix Metalloproteinase 13/Tissue Inhibitor of Metalloproteinase 1 Expression in Murine Silicosis. Am. J. Respir. Crit. Care Med. 163: 244-252 [Abstract] [Full Text]
Lapchak, P. A., Chapman, D. F., Zivin, J. A., Hsu, C. Y. (2000). Metalloproteinase Inhibition Reduces Thrombolytic (Tissue Plasminogen Activator)-Induced Hemorrhage After Thromboembolic Stroke Editorial Comment. Stroke 31: 3034-3040 [Abstract] [Full Text]
Spencer-Green, G. (2000). Etanercept (Enbrel): update on therapeutic use. Ann Rheum Dis 59: i46-49 [Abstract] [Full Text]
Williams, R. O, Feldmann, M., Maini, R. N (2000). Cartilage destruction and bone erosion in arthritis: the role of tumour necrosis factor alpha. Ann Rheum Dis 59: i75-80 [Full Text]
Skold, C. M., Liu, X. D., Umino, T., Zhu, Y. K., Ertl, R. F., Romberger, D. J., Rennard, S. I. (2000). Blood monocytes attenuate lung fibroblast contraction of three-dimensional collagen gels in coculture. Am. J. Physiol. Lung Cell. Mol. Physiol. 279: L667-L674 [Abstract] [Full Text]
Shao, J.-s., Sartor, R. B., Dial, E., Lichtenberger, L. M., Schepp, W., Alpers, D. H. (2000). Expression of Intrinsic Factor in Rat and Murine Gastric Mucosal Cell Lineages Is Modified by Inflammation. Am. J. Pathol. 157: 1197-1205 [Abstract] [Full Text]
Bresnihan, B., Tak, P. P., Emery, P., Klareskog, L., Breedveld, F. (2000). Synovial biopsy in arthritis research: five years of concerted European collaboration. Ann Rheum Dis 59: 506-511 [Full Text]
Li, P., Sanz, I., O'Keefe, R. J., Schwarz, E. M. (2000). NF-{kappa}B Regulates VCAM-1 Expression on Fibroblast-Like Synoviocytes. J. Immunol. 164: 5990-5997 [Abstract] [Full Text]
Seitz, M., Dayer, J.-M. (2000). Enhanced production of tissue inhibitor of metalloproteinases by peripheral blood mononuclear cells of rheumatoid arthritis patients responding to methotrexate treatment. Rheumatology (Oxford) 39: 637-645 [Abstract] [Full Text]
Vancheri, C., Sortino, M. A., Tomaselli, V., Mastruzzo, C., Condorelli, F., Bellistrí, G., Pistorio, M. P., Canonico, P. L., Crimi, N. (2000). Different Expression of TNF-alpha Receptors and Prostaglandin E2 Production in Normal and Fibrotic Lung Fibroblasts . Potential Implications for the Evolution of the Inflammatory Process. Am. J. Respir. Cell Mol. Bio. 22: 628-634 [Abstract] [Full Text]
Rooney, M., Varsani, H., Martin, K., Lombard, P. R., Dayer, J.-M., Woo, P. (2000). Tumour necrosis factor alpha and its soluble receptors in juvenile chronic arthritis. Rheumatology (Oxford) 39: 432-438 [Abstract] [Full Text]
Lovell, D. J., Giannini, E. H., Reiff, A., Cawkwell, G. D., Silverman, E. D., Nocton, J. J., Stein, L. D., Gedalia, A., Ilowite, N. T., Wallace, C. A., Whitmore, J., Finck, B. K., The Pediatric Rheumatology Collaborative Study Gro, (2000). Etanercept in Children with Polyarticular Juvenile Rheumatoid Arthritis. NEJM 342: 763-769 [Abstract] [Full Text]
Fox, D. A. (2000). Cytokine Blockade as a New Strategy to Treat Rheumatoid Arthritis: Inhibition of Tumor Necrosis Factor. Arch Intern Med 160: 437-444 [Abstract] [Full Text]
Johnson, M. L., Murdoch, J., Van Kirk, E. A., Kaltenbach, J. E., Murdoch, W. J. (1999). Tumor Necrosis Factor {alpha} Regulates Collagenolytic Activity in Preovulatory Ovine Follicles: Relationship to Cytokine Secretion by the Oocyte-Cumulus Cell Complex. Biol. Reprod. 61: 1581-1585 [Abstract] [Full Text]
Vallières, L., Rivest, S. (1999). Interleukin-6 Is a Needed Proinflammatory Cytokine in the Prolonged Neural Activity and Transcriptional Activation of Corticotropin-Releasing Factor during Endotoxemia. Endocrinology 140: 3890-3903 [Abstract] [Full Text]
Manabe, N., Oda, H., Nakamura, K., Kuga, Y., Uchida, S., Kawaguchi, H. (1999). Involvement of fibroblast growth factor-2 in joint destruction of rheumatoid arthritis patients. Rheumatology (Oxford) 38: 714-720 [Abstract] [Full Text]
Toi, M., Ueno, T., Matsumoto, H., Saji, H., Funata, N., Koike, M., Tominaga, T. (1999). Significance of Thymidine Phosphorylase as a Marker of Protumor Monocytes in Breast Cancer. Clin. Cancer Res. 5: 1131-1137 [Abstract] [Full Text]
Murdoch, W. J., Van Kirk, E. A., Murdoch, J. (1999). Plasmin Cleaves Tumor Necrosis Factor {alpha} Exodomain from Sheep Follicular Endothelium: Implication in the Ovulatory Process. Biol. Reprod. 60: 1166-1171 [Abstract] [Full Text]
Myokai, F., Takashiba, S., Lebo, R., Amar, S. (1999). A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha �gene expression: Molecular cloning, sequencing, characterization, and chromosomal assignment. Proc. Natl. Acad. Sci. USA 96: 4518-4523 [Abstract] [Full Text]
Moreland, L. W., Schiff, M. H., Baumgartner, S. W., Tindall, E. A., Fleischmann, R. M., Bulpitt, K. J., Weaver, A. L., Keystone, E. C., Furst, D. E., Mease, P. J., Ruderman, E. M., Horwitz, D. A., Arkfeld, D. G., Garrison, L., Burge, D. J., Blosch, C. M., Lange, M. L.M., McDonnell, N. D., Weinblatt, M. E. (1999). Etanercept Therapy in Rheumatoid Arthritis: A Randomized, Controlled Trial. ANN INTERN MED 130: 478-486 [Abstract] [Full Text]
Sarkissian, M., Lafyatis, R. (1999). Integrin Engagement Regulates Proliferation and Collagenase Expression of Rheumatoid Synovial Fibroblasts. J. Immunol. 162: 1772-1779 [Abstract] [Full Text]
Weinblatt, M. E., Kremer, J. M., Bankhurst, A. D., Bulpitt, K. J., Fleischmann, R. M., Fox, R. I., Jackson, C. G., Lange, M., Burge, D. J. (1999). A Trial of Etanercept, a Recombinant Tumor Necrosis Factor Receptor:Fc Fusion Protein, in Patients with Rheumatoid Arthritis Receiving Methotrexate. NEJM 340: 253-259 [Abstract] [Full Text]
Daum, S, Bauer, U, Foss, H-D, Schuppan, D, Stein, H, Riecken, E-O, Ullrich, R (1999). Increased expression of mRNA for matrix metalloproteinases-1 and -3�and tissue inhibitor of metalloproteinases-1 in intestinal biopsy specimens from patients with coeliac disease. Gut 44: 17-25 [Abstract] [Full Text]
Li, Y.-p., Schwartz, R. J., Waddell, I. D., Holloway, B. R., Reid, M. B. (1998). Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-{kappa}B activation in response to tumor necrosis factor {alpha}. FASEB J. 12: 871-880 [Abstract] [Full Text]
Chabaud, M., Fossiez, F., Taupin, J.-L., Miossec, P. (1998). Enhancing Effect of IL-17 on IL-1-Induced IL-6 and Leukemia Inhibitory Factor Production by Rheumatoid Arthritis Synoviocytes and Its Regulation by Th2 Cytokines. J. Immunol. 161: 409-414 [Abstract] [Full Text]
Tam, V. K., Schotland, S., Green, J. (1998). Inflammatory cytokines (IL-1alpha , TNF-alpha ) and LPS modulate the Ca2+ signaling pathway in osteoblasts. Am. J. Physiol. Cell Physiol. 274: C1686-C1698 [Abstract] [Full Text]
Houglum, K., Buck, M., Kim, D. J., Chojkier, M. (1998). TNF-alpha inhibits liver collagen-alpha 1(I) gene expression through a tissue-specific regulatory region. Am. J. Physiol. Gastrointest. Liver Physiol. 274: G840-G847 [Abstract] [Full Text]
Gorivodsky, M., Zemlyak, I., Orenstein, H., Savion, S., Fein, A., Torchinsky, A., Toder, V. (1998). TNF-{alpha} Messenger RNA and Protein Expression in the Uteroplacental Unit of Mice with Pregnancy Loss. J. Immunol. 160: 4280-4288 [Abstract] [Full Text]
Pender, S. L. F., Fell, J. M. E., Chamow, S. M., Ashkenazi, A., MacDonald, T. T. (1998). A p55 TNF Receptor Immunoadhesin Prevents T Cell-Mediated Intestinal Injury by Inhibiting Matrix Metalloproteinase Production. J. Immunol. 160: 4098-4103 [Abstract] [Full Text]
Webb, K. E., Henney, A. M., Anglin, S., Humphries, S. E., McEwan, J. R. (1997). Expression of Matrix Metalloproteinases and Their Inhibitor TIMP-1 in the Rat Carotid Artery After Balloon Injury. Arterioscler. Thromb. Vasc. Bio. 17: 1837-1844 [Abstract] [Full Text]
Firestein, G. S., Zvaifler, N. J. (1997). Anticytokine Therapy in Rheumatoid Arthritis. NEJM 337: 195-197 [Full Text]
Yokoyama, T., Nakano, M., Bednarczyk, J. L., McIntyre, B. W., Entman, M., Mann, D. L. (1997). Tumor Necrosis Factor-{alpha} Provokes a Hypertrophic Growth Response in Adult Cardiac Myocytes. Circulation 95: 1247-1252 [Abstract] [Full Text]
Nicol, G. D., Lopshire, J. C., Pafford, C. M. (1997). Tumor Necrosis Factor Enhances the Capsaicin Sensitivity of Rat Sensory Neurons. J. Neurosci. 17: 975-982 [Abstract] [Full Text]
Bazzoni, F., Beutler, B. (1996). The Tumor Necrosis Factor Ligand and Receptor Families. NEJM 334: 1717-1725 [Full Text]
Bachus, K. E., Doty, E., Haney, A. F., Weinberg, J. B. (1995). Differential Effects of Interleukin-I{alpha}, Tumor Necrosis Factor-{alpha}, Indomethacin, Hydrocortisone, and Macrophage Co-Culture on the Proliferation of Human Fibroblasts and Peritoneal Mesothelial Cells. Reproductive Sciences 2: 636-642 [Abstract]
Smith, C., Davis, T, Anderson, D, Solam, L, Beckmann, M., Jerzy, R, Dower, S., Cosman, D, Goodwin, R. (1990). A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science 248: 1019-1023 [Abstract]
Davatelis, G, Wolpe, S., Sherry, B, Dayer, J., Chicheportiche, R, Cerami, A (1989). Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen. Science 243: 1066-1068 [Abstract]
Brinckerhoff, C., Mitchell, T., Karmilowicz, M., Kluve-Beckerman, B, Benson, M. (1989). Autocrine induction of collagenase by serum amyloid A-like and beta 2-microglobulin-like proteins. Science 243: 655-657 [Abstract]
Vlassara, H, Brownlee, M, Manogue, K., Dinarello, C., Pasagian, A (1988). Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling. Science 240: 1546-1548 [Abstract]
Lotz, M, Carson, D., Vaughan, J. (1987). Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis. Science 235: 893-895 [Abstract]