The Journal of Experimental Medicine
Torrey Pines Biolabs
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Journal of Experimental Medicine, Vol 162, 762-767, Copyright © 1985 by Rockefeller University Press

ARTICLES

Fibronectin receptor of human macrophages recognizes the sequence Arg- Gly-Asp-Ser

SD Wright and BC Meyer

When cultured human monocytes (MO) were spread on fibronectin (Fn)- coated surfaces, C3 receptors on the MO exhibited markedly enhanced capacity to promote phagocytosis. The activation of C3 receptors by Fn was mediated by a receptor that recognizes a sequence, Arg-Gly-Asp-Ser (RGDS), present in the cell-binding domain of Fn. Soluble, RGDS- containing peptides inhibited the activation of C3 receptors caused by surface-bound Fn, and surface-bound, RGDS-containing peptides themselves caused activation of the C3 receptors of attached MO. Although soluble, RGDS-containing peptides bound to Fn receptors, such monovalent ligation was insufficient to activate C3 receptors.
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