Pilus- gonococcal variants. Evidence for multiple forms of piliation control

doi:10.1084/jem.162.2.729

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Pilus- gonococcal variants. Evidence for multiple forms of piliation control

J Swanson, S Bergstrom, O Barrera, K Robbins and D Corwin

Pilus+ to pilus- transitions of gonococci (Gc) that involve rearrangement of pilin gene DNA yield the P-n phenotype, which is incapable of reversion (to pilus+). Reversion to pilus+ is found for nonpiliated Gc that have undergone no apparent pilin gene rearrangement. Among the reverting, nonpiliated Gc, two distinct phenotypes (P-rp- and P-rp+) occur and are differentiated according to their synthesis (or lack) of pilin subunits; both P-rp- and P-rp+ Gc contain pilin-specific mRNA. The occurrence of these different pilus- phenotypes strongly suggests that several mechanisms can account for changes in the piliation status of Gc; one of these involves pilin gene rearrangement but the others apparently operate at posttranscriptional levels. Reverting pilus- Gc may have a pathogenic advantage in being able to reversibly alter their host cell adherence-promoting surface properties through high frequency transitions in piliation status.
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Giron, J., Ho, A., Schoolnik, G. (1991). An inducible bundle-forming pilus of enteropathogenic Escherichia coli. Science 254: 710-713 [Abstract]
Borst, P, Greaves, D. (1987). Programmed gene rearrangements altering gene expression. Science 235: 658-667 [Abstract]