Journal of Experimental Medicine, Vol 160, 905-913, Copyright © 1984 by Rockefeller University Press

ARTICLES

Murine T cell receptor beta chain is encoded on chromosome 6

NE Lee, P D'Eustachio, D Pravtcheva, FH Ruddle, SM Hedrick and MM Davis

Southern blot analysis of somatic cell hybrid lines indicates that the beta chain of the T cell receptor for antigen maps to chromosome 6 of the mouse. An experiment testing hybridization of the constant region of this gene to DNA from a hybrid cell line containing a translocation of chromosome 6 supports the localization of this gene to the proximal (centromeric) one-third of chromosome 6, in the same general region as the immunoglobulin kappa chain locus. This may be another indication of the shared evolutionary origins of the genes encoding both T and B cell antigen recognition.
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