The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs

doi:10.1084/jem.158.5.1522

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The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs

DA Hume, AP Robinson, GG MacPherson and S Gordon

The macrophage-specific antigen F4/80 has been localized in mouse lymphoid and hematopoietic tissue and skin using immunoperoxidase staining. The antigen permits identification of early mononuclear phagocyte precursors in the bone marrow, and is present also on larger cells forming the center of hematopoietic islands and lining vascular sinuses. In thymus F4/80+ cells are numerous in both cortex and medulla and are particularly concentrated around the corticomedullary region. In spleen, lymph node, and gut-associated lymphoid areas the major F4/80+ populations are in the red pulp, the medulla and subcapsular sinus, and the adjacent lamina propria, respectively. F4/80+ cells are rarely seen in T-dependent areas of lymph nodes, spleen, or Peyer's patch, but are present in large numbers in these areas during bacillus Calmette-Guerin (BCG)-induced inflammation. Macrophage infiltration occurs also in lymph nodes from athymic nu/nu mice and is therefore T cell independent. The interdigitating cell of T-dependent areas is F4/80-, but the Langerhans cell of the epidermis of the skin, which bears some ultrastructural resemblance to the interdigitating cell, is F4/80+. We conclude that the two cell types are probably not related.
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Tirziu, D., Moodie, K. L., Zhuang, Z. W., Singer, K., Helisch, A., Dunn, J. F., Li, W., Singh, J., Simons, M. (2005). Delayed Arteriogenesis in Hypercholesterolemic Mice. Circulation 112: 2501-2509 [Abstract] [Full Text]
Geutskens, S. B., Otonkoski, T., Pulkkinen, M-A., Drexhage, H. A., Leenen, P. J. M. (2005). Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro. J. Leukoc. Biol. 78: 845-852 [Abstract] [Full Text]
Sato, K., Imai, Y., Higashi, N., Kumamoto, Y., Mukaida, N., Irimura, T. (2005). Redistributions of macrophages expressing the macrophage galactose-type C-type lectin (MGL) during antigen-induced chronic granulation tissue formation. Int Immunol 17: 559-568 [Abstract] [Full Text]
Suzuki, K., Suda, T., Naito, T., Ide, K., Chida, K., Nakamura, H. (2005). Impaired Toll-like Receptor 9 Expression in Alveolar Macrophages with No Sensitivity to CpG DNA. Am. J. Respir. Crit. Care Med. 171: 707-713 [Abstract] [Full Text]
Gatto, D., Ruedl, C., Odermatt, B., Bachmann, M. F. (2004). Rapid Response of Marginal Zone B Cells to Viral Particles. J. Immunol. 173: 4308-4316 [Abstract] [Full Text]
Crisman, J. M., Zhang, B., Norman, L. P., Bond, J. S. (2004). Deletion of the Mouse Meprin {beta} Metalloprotease Gene Diminishes the Ability of Leukocytes to Disseminate through Extracellular Matrix. J. Immunol. 172: 4510-4519 [Abstract] [Full Text]
Cozzio, A., Passegue, E., Ayton, P. M., Karsunky, H., Cleary, M. L., Weissman, I. L. (2003). Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 17: 3029-3035 [Abstract] [Full Text]
Suzuki, Y., Gomez-Guerrero, C., Shirato, I., Lopez-Franco, O., Gallego-Delgado, J., Sanjuan, G., Lazaro, A., Hernandez-Vargas, P., Okumura, K., Tomino, Y., Ra, C., Egido, J. (2003). Pre-Existing Glomerular Immune Complexes Induce Polymorphonuclear Cell Recruitment Through an Fc Receptor-Dependent Respiratory Burst: Potential Role in the Perpetuation of Immune Nephritis. J. Immunol. 170: 3243-3253 [Abstract] [Full Text]
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Schaller, E., Macfarlane, A. J., Rupec, R. A., Gordon, S., McKnight, A. J., Pfeffer, K. (2002). Inactivation of the F4/80 Glycoprotein in the Mouse Germ Line. Mol. Cell. Biol. 22: 8035-8043 [Abstract] [Full Text]
Stacey, M., Chang, G.-W., Sanos, S. L., Chittenden, L. R., Stubbs, L., Gordon, S., Lin, H.-H. (2002). EMR4, a Novel Epidermal Growth Factor (EGF)-TM7 Molecule Up-regulated in Activated Mouse Macrophages, Binds to a Putative Cellular Ligand on B Lymphoma Cell Line A20. J. Biol. Chem. 277: 29283-29293 [Abstract] [Full Text]
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Skovseth, D. K., Yamanaka, T., Brandtzaeg, P., Butcher, E. C., Haraldsen, G. (2002). Vascular Morphogenesis and Differentiation after Adoptive Transfer of Human Endothelial Cells to Immunodeficient Mice. Am. J. Pathol. 160: 1629-1637 [Abstract] [Full Text]
Cohen, P. E., Zhu, L., Nishimura, K., Pollard, J. W. (2002). Colony-Stimulating Factor 1 Regulation of Neuroendocrine Pathways that Control Gonadal Function in Mice. Endocrinology 143: 1413-1422 [Abstract] [Full Text]
Abe, M., Cheng, J., Qi, J., Glaser, R. M., Thall, A. D., Sykes, M., Yang, Y.-G. (2002). Elimination of Porcine Hemopoietic Cells by Macrophages in Mice. J. Immunol. 168: 621-628 [Abstract] [Full Text]
Byersdorfer, C. A., Chaplin, D. D. (2001). Visualization of Early APC/T Cell Interactions in the Mouse Lung Following Intranasal Challenge. J. Immunol. 167: 6756-6764 [Abstract] [Full Text]
Palframan, R. T., Jung, S., Cheng, G., Weninger, W., Luo, Y., Dorf, M., Littman, D. R., Rollins, B. J., Zweerink, H., Rot, A., von Andrian, U. H. (2001). Inflammatory Chemokine Transport and Presentation in HEV: A Remote Control Mechanism for Monocyte Recruitment to Lymph Nodes in Inflamed Tissues. J. Exp. Med. 194: 1361-1374 [Abstract] [Full Text]
Novak, N., Bieber, T., Katoh, N. (2001). Engagement of Fc{{epsilon}}RI on Human Monocytes Induces the Production of IL-10 and Prevents Their Differentiation in Dendritic Cells. J. Immunol. 167: 797-804 [Abstract] [Full Text]
Hemmi, H., Yoshino, M., Yamazaki, H., Naito, M., Iyoda, T., Omatsu, Y., Shimoyama, S., Letterio, J. J., Nakabayashi, T., Tagaya, H., Yamane, T., Ogawa, M., Nishikawa, S.-I., Ryoke, K., Inaba, K., Hayashi, S.-I., Kunisada, T. (2001). Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-{beta}1-dependent cells. Int Immunol 13: 695-704 [Abstract] [Full Text]
Faunce, D. E., Sonoda, K.-H., Stein-Streilein, J. (2001). MIP-2 Recruits NKT Cells to the Spleen During Tolerance Induction. J. Immunol. 166: 313-321 [Abstract] [Full Text]
Yamagishi, H., Yokoo, T., Imasawa, T., Mitarai, T., Kawamura, T., Utsunomiya, Y. (2001). Genetically Modified Bone Marrow-Derived Vehicle Cells Site Specifically Deliver an Anti-Inflammatory Cytokine to Inflamed Interstitium of Obstructive Nephropathy. J. Immunol. 166: 609-616 [Abstract] [Full Text]
Sluyter, R., Halliday, G. M. (2000). Enhanced tumor growth in UV-irradiated skin is associated with an influx of inflammatory cells into the epidermis. Carcinogenesis 21: 1801-1807 [Abstract] [Full Text]
Nestel, F. P., Greene, R. N., Kichian, K., Ponka, P., Lapp, W. S. (2000). Activation of macrophage cytostatic effector mechanisms during acute graft-versus-host disease: release of intracellular iron and nitric oxide-mediated cytostasis. Blood 96: 1836-1843 [Abstract] [Full Text]
Warschkau, H., Kiderlen, A. F. (1999). A Monoclonal Antibody Directed Against the Murine Macrophage Surface Molecule F4/80 Modulates Natural Immune Response to Listeria monocytogenes. J. Immunol. 163: 3409-3416 [Abstract] [Full Text]
de Bont, E. S. J. M., Reilly, C. R., Lo, D., Glimcher, L. H., Laufer, T. M. (1999). A minimal level of MHC class II expression is sufficient to abrogate autoreactivity. Int Immunol 11: 1295-1306 [Abstract] [Full Text]
Le Bon, A., Wache, A.-C., Papiernik, M. (1999). In vivo elimination of viral superantigen-activated CD4+ T cells: apoptosis occurs at a distance from the activation site. Int Immunol 11: 373-382 [Abstract] [Full Text]
Talts, J., Wirl, G, Dictor, M, Muller, W., Fassler, R (1999). Tenascin-C modulates tumor stroma and monocyte/macrophage recruitment but not tumor growth or metastasis in a mouse strain with spontaneous mammary cancer. J. Cell Sci. 112: 1855-1864 [Abstract]
Oliveira-dos-Santos, A. J., Rieker-Geley, T., Recheis, H., Wick, G. (1997). Murine Thymic Nurse Cells and Rosettes: Analysis of Adhesion Molecule Expression Using Confocal Microscopy and a Simplified Enrichment Method. J. Histochem. Cytochem. 45: 1293-1298 [Abstract] [Full Text]
Inaba, K., Pack, M., Inaba, M., Sakuta, H., Isdell, F., Steinman, R. M. (1997). High Levels of a Major Histocompatibility Complex II-Self Peptide Complex on Dendritic Cells from the T Cell Areas of Lymph Nodes. J. Exp. Med. 186: 665-672 [Abstract] [Full Text]
McKnight, A. J., Macfarlane, A. J., Dri, P., Turley, L., Willis, A. C., Gordon, S. (1996). Molecular Cloning of F4/80, a Murine Macrophage-restricted Cell Surface Glycoprotein with Homology to the G-protein-linked Transmembrane 7 Hormone Receptor Family. J. Biol. Chem. 271: 486-489 [Abstract] [Full Text]
Cecchini, M., Dominguez, M., Mocci, S, Wetterwald, A, Felix, R, Fleisch, H, Chisholm, O, Hofstetter, W, Pollard, J., Stanley, E. (1994). Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse. Development 120: 1357-1372 [Abstract]
Witmer-Pack, M., Crowley, M., Inaba, K, Steinman, R. (1993). Macrophages, but not dendritic cells, accumulate colloidal carbon following administration in situ. J. Cell Sci. 105: 965-973 [Abstract]
Ruff, M., Pert, C. (1984). Small cell carcinoma of the lung: macrophage-specific antigens suggest hemopoietic stem cell origin. Science 225: 1034-1036 [Abstract]