Fibronectin and serum amyloid P component stimulate C3b- and C3bi- mediated phagocytosis in cultured human monocytes

doi:10.1084/jem.158.4.1338

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Wright, S. D.
	Articles by Silverstein, S. C.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Wright, S. D.
	Articles by Silverstein, S. C.


Social Bookmarking

	What's this?

ARTICLES

Fibronectin and serum amyloid P component stimulate C3b- and C3bi- mediated phagocytosis in cultured human monocytes

SD Wright, LS Craigmyle and SC Silverstein

Fibronectin (FN) and serum amyloid P component (SAP) markedly enhance phagocytosis mediated by the C3b and C3bi receptors of cultured human monocytes but not of granulocytes. (The C3b and C3bi receptors of granulocytes can be activated by treatment of these phagocytes with PMA.) Activation of monocyte C3 receptors by FN is developmentally regulated: Freshly explanted monocytes respond to FN with a small increase in C3 receptor-mediated phagocytosis while monocytes matured in culture exhibit a much greater response. The mechanism of action of FN on C3 receptors of cultured monocytes is unique in two respects. First, while substrate-bound FN or SAP activate monocyte C3 receptors, soluble FN does not. Second, stimulation of the basal surface of monocyte plasma membranes by substrate-bound FN activates C3b and C3bi receptors on the apical surface of the plasma membrane, i.e., at sites remote from the segments of membrane in contact with the FN or SAP.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Vachon, E., Martin, R., Kwok, V., Cherepanov, V., Chow, C.-W., Doerschuk, C. M., Plumb, J., Grinstein, S., Downey, G. P. (2007). CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages. Blood 110: 4492-4502 [Abstract] [Full Text]
Diks, S. H., van Deventer, S. J.H., Peppelenbosch, M. P. (2001). Invited review: Lipopolysaccharide recognition, internalisation, signalling and other cellular effects. Innate Immunity 7: 335-348 [Abstract]
Bharadwaj, D., Mold, C., Markham, E., Du Clos, T. W. (2001). Serum Amyloid P Component Binds to Fc{{gamma}} Receptors and Opsonizes Particles for Phagocytosis. J. Immunol. 166: 6735-6741 [Abstract] [Full Text]
Ghiran, I., Barbashov, S. F., Klickstein, L. B., Tas, S. W., Jensenius, J. C., Nicholson-Weller, A. (2000). Complement Receptor 1/CD35 Is a Receptor for Mannan-binding Lectin. J. Exp. Med. 192: 1797-1808 [Abstract] [Full Text]
Gommerman, J. L., Oh, D. Y., Zhou, X., Tedder, T. F., Maurer, M., Galli, S. J., Carroll, M. C. (2000). A Role for CD21/CD35 and CD19 in Responses to Acute Septic Peritonitis: A Potential Mechanism for Mast Cell Activation. J. Immunol. 165: 6915-6921 [Abstract] [Full Text]
de Haas, C. J. C., van Leeuwen, E. M. M., van Bommel, T., Verhoef, J., van Kessel, K. P. M., van Strijp, J. A. G. (2000). Serum Amyloid P Component Bound to Gram-Negative Bacteria Prevents Lipopolysaccharide-Mediated Classical Pathway Complement Activation. Infect. Immun. 68: 1753-1759 [Abstract] [Full Text]
Peiser, L., Gough, P. J., Kodama, T., Gordon, S. (2000). Macrophage Class A Scavenger Receptor-Mediated Phagocytosis of Escherichia coli: Role of Cell Heterogeneity, Microbial Strain, and Culture Conditions In Vitro. Infect. Immun. 68: 1953-1963 [Abstract] [Full Text]
Sabri, S, Soler, M, Foa, C, Pierres, A, Benoliel, A, Bongrand, P (2000). Glycocalyx modulation is a physiological means of regulating cell adhesion. J. Cell Sci. 113: 1589-1600 [Abstract]
Brittingham, A., Chen, G., McGwire, B. S., Chang, K.-P., Mosser, D. M. (1999). Interaction of Leishmania gp63 with Cellular Receptors for Fibronectin. Infect. Immun. 67: 4477-4484 [Abstract] [Full Text]
de Haas, C. J. C., van der Tol, M. E., Van Kessel, K. P. M., Verhoef, J., Van Strijp, J. A. G. (1998). A Synthetic Lipopolysaccharide-Binding Peptide Based on Amino Acids 27-39 of Serum Amyloid P Component Inhibits Lipopolysaccharide-Induced Responses in Human Blood. J. Immunol. 161: 3607-3615 [Abstract] [Full Text]
Rossi, A. G., McCutcheon, J. C., Roy, N., Chilvers, E. R., Haslett, C., Dransfield, I. (1998). Regulation of Macrophage Phagocytosis of Apoptotic Cells by cAMP. J. Immunol. 160: 3562-3568 [Abstract] [Full Text]
Simon, K. O., Nutt, E. M., Abraham, D. G., Rodan, G. A., Duong, L. T. (1997). The alpha vbeta 3 Integrin Regulates alpha 5beta 1-mediated Cell Migration toward Fibronectin. J. Biol. Chem. 272: 29380-29389 [Abstract] [Full Text]
Joiner, K., Fuhrman, S., Miettinen, H., Kasper, L., Mellman, I (1990). Toxoplasma gondii: fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblasts. Science 249: 641-646 [Abstract]