The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 158, 1307-1318, Copyright © 1983 by Rockefeller University Press

ARTICLES

Studies on the syngeneic mixed lymphocyte reaction. III. Development of a monoclonal antibody with specificity for autoreactive T cells

PB Hausman, CE Moody, JB Innes, JJ Gibbons and ME Weksler

Monoclonal antibodies with specificity for autoreactive murine T cells have been developed. These antibodies inhibit proliferative response of splenic T cells activated by syngeneic spleen cells. These antibodies have no effect on the proliferative response of T cells activated by allogeneic spleen cells or PHA. The number of splenic T cells that react with these monoclonal antibodies is comparable in several normal mouse strains.
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