Journal of Experimental Medicine, Vol 158, 1294-1306, Copyright © 1983 by Rockefeller University Press
Altered transcription of genes coding for class I histocompatibility antigens in murine tumor cells
P Baldacci, F Pozo, S Gisselbrecht and P Kourilsky
Three murine tumors induced by Moloney murine leukemia virus (M-MLV) which
exhibited loss of some or all H-2 class I antigens at the cell surface were
analyzed at the DNA and RNA level with molecular probes specific of H-2
heavy chains and beta 2-microglobulin sequences. No observable difference
could be detected at the DNA level between the tumors and the parent
animals. However, a decrease in H-2 mRNA was observed, especially in
phenotypically H-2 negative tumor, BM5R, where H-2 transcripts were at
least 30-fold less abundant. These results show that an H-2-negative
character may result from a general alteration in the transcription of H-2
genes, which could reflect some kind of regulatory process.
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