Journal of Experimental Medicine, Vol 158, 1243-1258, Copyright © 1983 by Rockefeller University Press
Lysis of inducer T cell clones by activated macrophages and macrophage- like cell lines
A Rao, SJ Faas, LJ Miller, PS Riback and H Cantor
We describe a sequence of reciprocal interactions between cloned inducer T
cells and antigen-presenting cells (APC) that results in selective
depletion of the antigen-reactive inducer cells. We show that corecognition
of antigen and I-A by hapten-reactive inducer T cell clones results in (a)
release of macrophage-activating factor (MAF) and other lymphokines, (b)
expression of lytic activity by a subset of MAF- sensitized APC after
triggering, and (3) lysis (mediated by the activated and triggered
macrophage) of the inducer T cell clone and other cells in the vicinity. We
suggest that this sequence of steps may limit the extent of
macrophage-mediated tissue destruction by depleting the specific inducer T
cell clones that initiate the response.
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