Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation

doi:10.1084/jem.158.3.781

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Elmets, C. A.
	Articles by Streilein, J. W.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Elmets, C. A.
	Articles by Streilein, J. W.


Social Bookmarking

	What's this?

ARTICLES

Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation

CA Elmets, PR Bergstresser, RE Tigelaar, PJ Wood and JW Streilein

Acute, low dose ultraviolet B radiation of murine body wall skin followed by local application of DNFB produces a state of antigen- specific unresponsiveness. This state is maintained at least in part by an Lyt-1+ T cell that effects unresponsiveness by impairing the induction phase of contact hypersensitivity. The absence of suppressor cells capable of acting at the effector stage of immunity suggests that tolerogenic signals derived from the skin establish suppressor networks that are incomplete and perhaps different from networks that are induced by systemic administration of tolerogens. It is proposed that ultraviolet radiation produces its effects by impairing the antigen- presenting potential of resident Langerhans cells in whose absence hapten-derivatized keratinocytes (or their products) are able to deliver a tolerogenic signal.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Pradhan, S., Kim, H. K., Thrash, C. J., Cox, M. A., Mantena, S. K., Wu, J.-H., Athar, M., Katiyar, S. K., Elmets, C. A., Timares, L. (2008). A Critical Role for the Proapoptotic Protein Bid in Ultraviolet-Induced Immune Suppression and Cutaneous Apoptosis. J. Immunol. 181: 3077-3088 [Abstract] [Full Text]
Maeda, A., Beissert, S., Schwarz, T., Schwarz, A. (2008). Phenotypic and Functional Characterization of Ultraviolet Radiation-Induced Regulatory T Cells. J. Immunol. 180: 3065-3071 [Abstract] [Full Text]
Loser, K., Apelt, J., Voskort, M., Mohaupt, M., Balkow, S., Schwarz, T., Grabbe, S., Beissert, S. (2007). IL-10 Controls Ultraviolet-Induced Carcinogenesis in Mice. J. Immunol. 179: 365-371 [Abstract] [Full Text]
Schwarz, A., Maeda, A., Schwarz, T. (2007). Alteration of the Migratory Behavior of UV-Induced Regulatory T Cells by Tissue-Specific Dendritic Cells. J. Immunol. 178: 877-886 [Abstract] [Full Text]
Ghoreishi, M., Dutz, J. P. (2006). Tolerance Induction by Transcutaneous Immunization through Ultraviolet-Irradiated Skin Is Transferable through CD4+CD25+ T Regulatory Cells and Is Dependent on Host-Derived IL-10. J. Immunol. 176: 2635-2644 [Abstract] [Full Text]
Riemann, H., Loser, K., Beissert, S., Fujita, M., Schwarz, A., Schwarz, T., Grabbe, S. (2005). IL-12 Breaks Dinitrothiocyanobenzene (DNTB)-Mediated Tolerance and Converts the Tolerogen DNTB into an Immunogen. J. Immunol. 175: 5866-5874 [Abstract] [Full Text]
Gorman, S., Tan, J. W.-Y., Thomas, J. A., Townley, S. L., Stumbles, P. A., Finlay-Jones, J. J., Hart, P. H. (2005). Primary Defect in UVB-Induced Systemic Immunomodulation Does Not Relate to Immature or Functionally Impaired APCs in Regional Lymph Nodes. J. Immunol. 174: 6677-6685 [Abstract] [Full Text]
Schwarz, A., Maeda, A., Kernebeck, K., van Steeg, H., Beissert, S., Schwarz, T. (2005). Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J. Exp. Med. 201: 173-179 [Abstract] [Full Text]
Rosenblum, M. D., Olasz, E., Woodliff, J. E., Johnson, B. D., Konkol, M. C., Gerber, K. A., Orentas, R. J., Sandford, G., Truitt, R. L. (2004). CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance. Blood 103: 2691-2698 [Abstract] [Full Text]
Schwarz, A., Maeda, A., Wild, M. K., Kernebeck, K., Gross, N., Aragane, Y., Beissert, S., Vestweber, D., Schwarz, T. (2004). Ultraviolet Radiation-Induced Regulatory T Cells Not Only Inhibit the Induction but Can Suppress the Effector Phase of Contact Hypersensitivity. J. Immunol. 172: 1036-1043 [Abstract] [Full Text]
Aragane, Y., Maeda, A., Schwarz, A., Tezuka, T., Ariizumi, K., Schwarz, T. (2003). Involvement of Dectin-2 in Ultraviolet Radiation-Induced Tolerance. J. Immunol. 171: 3801-3807 [Abstract] [Full Text]
Komura, K., Hasegawa, M., Hamaguchi, Y., Saito, E., Kaburagi, Y., Yanaba, K., Kawara, S., Takehara, K., Seki, M., Steeber, D. A., Tedder, T. F., Sato, S. (2003). Ultraviolet Light Exposure Suppresses Contact Hypersensitivity by Abrogating Endothelial Intercellular Adhesion Molecule-1 Up-Regulation at the Elicitation Site. J. Immunol. 171: 2855-2862 [Abstract] [Full Text]
Denfeld, R. W., Hara, H., Tesmann, J. P., Martin, S., Simon, J. C. (2001). UVB-irradiated dendritic cells are impaired in their APC function and tolerize primed Th1 cells but not naive CD4+ T cells. J. Leukoc. Biol. 69: 548-554 [Abstract] [Full Text]
Schwarz, A., Beissert, S., Grosse-Heitmeyer, K., Gunzer, M., Bluestone, J. A., Grabbe, S., Schwarz, T. (2000). Evidence for Functional Relevance of CTLA-4 in Ultraviolet-Radiation-Induced Tolerance. J. Immunol. 165: 1824-1831 [Abstract] [Full Text]
Carucci, J. A., Ignatius, R., Wei, Y., Cypess, A. M., Schaer, D. A., Pope, M., Steinman, R. M., Mojsov, S. (2000). Calcitonin Gene-Related Peptide Decreases Expression of HLA-DR and CD86 by Human Dendritic Cells and Dampens Dendritic Cell-Driven T Cell-Proliferative Responses Via the Type I Calcitonin Gene-Related Peptide Receptor. J. Immunol. 164: 3494-3499 [Abstract] [Full Text]
Simkin, G. O., Tao, J.-S., Levy, J. G., Hunt, D. W. C. (2000). IL-10 Contributes to the Inhibition of Contact Hypersensitivity in Mice Treated with Photodynamic Therapy. J. Immunol. 164: 2457-2462 [Abstract] [Full Text]
Katiyar, S. K., Challa, A., McCormick, T. S., Cooper, K. D., Mukhtar, H. (1999). Prevention of UVB-induced immunosuppression in mice by the green tea polyphenol (-)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production. Carcinogenesis 20: 2117-2124 [Abstract] [Full Text]
Hill, L. L., Shreedhar, V. K., Kripke, M. L., Owen-Schaub, L. B. (1999). A Critical Role for Fas Ligand in the Active Suppression of Systemic Immune Responses by Ultraviolet Radiation. J. Exp. Med. 189: 1285-1294 [Abstract] [Full Text]
Holan, V., Kuffova, L., Zajicova, A., Krulova, M., Filipec, M., Holler, P., Jancarek, A. (1998). Urocanic Acid Enhances IL-10 Production in Activated CD4+ T Cells. J. Immunol. 161: 3237-3241 [Abstract] [Full Text]
Shreedhar, V. K., Pride, M. W., Sun, Y., Kripke, M. L., Strickland, F. M. (1998). Origin and Characteristics of Ultraviolet-B Radiation-Induced Suppressor T Lymphocytes. J. Immunol. 161: 1327-1335 [Abstract] [Full Text]
Schwarz, A., Grabbe, S., Grosse-Heitmeyer, K., Roters, B., Riemann, H., Luger, T. A., Trinchieri, G., Schwarz, T. (1998). Ultraviolet Light-Induced Immune Tolerance Is Mediated via the Fas/Fas-Ligand System. J. Immunol. 160: 4262-4270 [Abstract] [Full Text]
Vink, A. A., Moodycliffe, A. M., Shreedhar, V., Ullrich, S. E., Roza, L., Yarosh, D. B., Kripke, M. L. (1997). The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored by in vitro photorepair of cyclobutane pyrimidine�dimers. Proc. Natl. Acad. Sci. USA 94: 5255-5260 [Abstract] [Full Text]