The Journal of Experimental Medicine
ThymUS '08
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Journal of Experimental Medicine, Vol 158, 1000-1005, Copyright © 1983 by Rockefeller University Press

ARTICLES

Idiotype-like molecules on cells of a human T cell leukemia

RD Bigler, DE Fisher, CY Wang, EA Rinnooy Kan and HG Kunkel

Two monoclonal antibodies were obtained that showed unique specificities for the leukemic T cells used for immunization. One antibody, S160, was totally specific for the antigen. The other antibody, S511, also reacted with a small population of normal T cells. This was made especially evident by concentrating these normal T cells with the antibody. Considerable evidence was obtained that both antibodies reacted with the same membrane molecules. In the unreduced state a major component of approximately 80 kdaltons was observed; after reduction this split into two components of approximately 43 and approximately 38 kdaltons. The reaction of the two antibodies with different antigenic sites on the same molecule, one representing a private site and the other a more cross-reactive site, strongly suggests an antibodylike molecule, but composed of polypeptide chains differing from immunoglobulins.
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