The Journal of Experimental Medicine
ThymUS '08
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Journal of Experimental Medicine, Vol 158, 99-111, Copyright © 1983 by Rockefeller University Press

ARTICLES

Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens

RS Mittler, PE Rao, MA Talle, R Look and G Goldstein

Three human lymphocyte antigens recognized by monoclonal antibodies OKIa1, OKT9, and OKT10 were found to be minimally represented on resting peripheral T cells (all three) and thymocytes (OKIa1 and OKT9). These antigens, which are present on "activated" T cells, were promptly displayed on "resting" T cells or thymocytes following cross-linking of surface-bound monoclonal antibody by horse alpha-mouse IgG. These experiments suggested that membrane perturbations may induce the expression of certain antigens that are normally present in an unexpressed form in resting cells.
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