The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 158, 9-15, Copyright © 1983 by Rockefeller University Press

ARTICLES

c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia

J Groffen, N Heisterkamp, JR Stephenson, AG van Kessel, A de Klein, G Grosveld and D Bootsma

By analysis of a series of somatic cell hybrids derived by fusion of either mouse or Chinese hamster cells with leukocytes from different chronic myelocytic leukemia (CML) patients or from normal donors, we have localized the human oncogene, c-sis, on the q11 to qter segment of chromosome 22 and demonstrated its translocation from chromosome 22 to chromosome 9 (q34) in CML.
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